Overview

The goal of this book is to show the high potential of chiral sulfur-containing ligands to promote numerous asymmetric catalytic transformations. The important number of reports appeared in the literature over the last 35 years often highlighted spectacular results in terms of efficiency and enantioselectivity, allowing access to many biologically important molecules, which clearly demonstrates that these ligands can now be recognised as real competitors to the more usual phosphorus- or nitrogen-containing ligands. A key point of reference for post-graduate students, researchers and academics.

Full Product Details

9781847559623

Table of Contents

Reviews

Intelligent Design Knowledge-Based Expert Systems in Chemistry (not counting on computers) Philip Judson RSC Publishing, Cambridge, UK, 2009, 211pp (HB) ISBN 9780854041602 Reviewed by Susan Boyd This is the first book in the RSC Theoretical and computational chemistry series and itself is a pioneer in the sense that it appears to be the only book to date devoted to the development of knowledge-based expert systems in chemistry and toxicology. The book, by its own admission, is aimed at practising computational and theoretical chemists, and students of these subjects. At first glance, I expected quite a dry textbook, but I was very pleasantly surprised as I meandered through the first couple of chapters. In fact, alongside the scientific detail, the book provides an engaging history of not only knowledge-based systems in chemistry, but also of the wider context of chemoinformatics, describing the key individuals instrumental in defining the science we now regard as standard, and some of the companies and products they created. Fascinating for those of us keen to explore the roots of our discipline. The subject matter ranges from defining artificial intelligence through to illustrating the use of rule-based systems by currently evolving software tools, thoroughly describing the fundamentals of computational structure representation and searching algorithms on the way. The book's publication is very timely, given the introduction of the Reach (registration, evaluation, authorisation, and restriction of chemicals) legislation which requires more information on chemical degradants than previously, and the Organisation for Economic Cooperation and Development recommendations on chemical hazard assessment, which promote replacement of some in vitro tests by in silico methods. Knowledge-based systems will surely have a role to play in these areas in future. All in all this is a very readable text, useful both for teaching purposes and a

Author Information

Helene Pellissier was born in Gap, France. She carried out her PhD under the supervision of Dr G. Gil in Marseille and then entered the Centre National de la Recherche Scientifique in 1988. After a postdoctoral position in Professor K. P. C. Vollhardt's group at Berkeley, she joined the group of Professor M. Santelli in Marseille in 1992. Here she focused on the chemistry of BISTRO and its large application in organic synthesis.

Tab Content 6

Customer Reviews

Recent Reviews

Countries Available