Overview

The primary focus of this book is on developing or selecting suitable chromatographic methods for chiral separations. A large number of examples are given to assist in this process, including thin-layer, gas, HPLC, supercritical fluid, capillary electrophoresis, and membrane separations. It provides information on stereochemistry, TLC, GLC, and CE separation methods and detection; explores the importance of preparative separations; and illustrates the stereoisomeric composition of chemical compounds of pharmaceutical significance. There is discussion of regulations and requirements as they apply to the development of pharmaceutical compounds, and a detailed section on HPLC methods.

Full Product Details

Author:   Satinder Ahuja
Publisher:   American Chemical Society
Imprint:   American Chemical Society
Dimensions:   Width: 16.20cm , Height: 1.70cm , Length: 24.30cm
Weight:   0.500kg
ISBN:  

9780841236318

ISBN 10:   0841236313
Pages:   240
Publication Date:   01 June 2000
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   No Longer Our Product
Availability:   In Print  
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Table of Contents

Chapter 1. An overview ; Chirality and biological activity ; Chiral separations ; Chiral stationary phases ; Modern CSP design ; Preparative separations ; Regulatory perspectives ; Chapter 2. Perspectives on Evaluation of Stereoisomers as Drug Candidates ; Marketing status of single isomers ; Development of single enantiomers ; Pharmacokinetics ; Detoxification ; Stability ; Industrial perspectives ; Regulatory guidelines ; Chapter 3. Review of Stereochemistry ; Brief history ; Stereoisomerism ; Classification ; Nomenclature ; Resolution ; Enantiopurity ; Determination of absolute configuration ; Chapter 4. Separation Methods ; Thin layer chromatography ; Gas chromatography ; High pressure liquid chromatography ; Supercritical fluid chromatography ; Capillary electrophoresis ; Chapter 5. Detection Methods ; Detectors for TLC ; Detectors for GC ; Detectors for HPLC ; Specific detectors for chiral compounds ; Chapter 6. Desirable Features of Chiral Stationary Phases ; Desirable features ; Types of CSPs ; Comparison of various CSPs ; Chapter 7. Understanding Chiral Chromatography ; Enantioselective interactions ; Chromatographic enantioselectivity ; Inclusion ; Transition metal complexes ; Separations on protein columns ; Molecular modeling ; Chapter 8. Method Development ; Stereoisomeric Interactions ; Chromatographic methods ; Chromatographic methods ; Modes of separation in HPLC ; Chromatography of diastereomeric derivatives ; Enantiomeric resolution using chiral mobile-phase additives ; Enantiomeric resolution using chiral stationary phases ; Computerized methods ; Chapter 9. Preparative Separations ; Displacement chromatography ; Elution chromatography ; Chapter 10. Method Selection and Selected Applications ; Where to start? ; Study the molecule ; Which method to use? ; High pressure liquid chromatography ; Gas chromatography ; Supercritical fluid chromatography (SFC) ; Capillary electrophoresis (CE) ; Comparative separations

Reviews

""" very timely ... This is a highly recommended volume for those wishing to learn about chiral chromatography from a practical viewpoint ... the book should be in every library"" Process Research and Development Journal"

Focuses on developing or selecting suitable chromatographic methods for chiral separations. Provides information on stereochemistry and separation and detection methods such as TLC, GLC, HPLC, and CE, and explores the importance of preparative separations. Illustrates the importance of investigating the stereoisomeric composition of chemical compounds of biological significance, and discusses regulations and requirements as they apply to the development of pharmaceutical compounds. The author is a consultant with many years of experience in research and development of new drugs. --SciTech Book News<br>

<br> Focuses on developing or selecting suitable chromatographic methods for chiral separations. Provides information on stereochemistry and separation and detection methods such as TLC, GLC, HPLC, and CE, and explores the importance of preparative separations. Illustrates the importance of investigating the stereoisomeric composition of chemical compounds of biological significance, and discusses regulations and requirements as they apply to the development of pharmaceutical compounds. The author is a consultant with many years of experience in research and development of new drugs. --SciTech Book News<p><br>

<br> Focuses on developing or selecting suitable chromatographic methods for chiral separations. Provides information on stereochemistry and separation and detection methods such as TLC, GLC, HPLC, and CE, and explores the importance of preparative separations. Illustrates the importance of investigating the stereoisomeric composition of chemical compounds of biological significance, and discusses regulations and requirements as they apply to the development of pharmaceutical compounds. The author is a consultant with many years of experience in research and development of new drugs. --SciTech Book News<br>

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