Overview

The key scientific discoveries of the 21st century will emerge from the biosciences. These discoveries will impact our lives in ways we can only now begin to imagine. In this book, two of the field's leading experts help us imagine those impacts. Paul and Joyce A. Schoemaker tour the remarkable field of biosciences as it stands today, and preview the directions and innovations that are most likely to emerge in the coming years. They offer a clear, non-technical overview of crucial current developments that are likely to have enormous impact, and address issues ranging from increased human longevity to global warming, bio-warfare to personalized medicine. Along the way, they illuminate each of the exciting technologies and hot-button issues associated with contemporary biotechnology - including stem cells, cloning, probiotics, DNA microarrays, proteomics, gene therapy, and a whole lot more. The Schoemakers identify emerging economic, political, and technical drivers and obstacles that are likely to powerfully impact the way the biosciences progress. Then, drawing on Paul Schoemaker's unsurpassed experience helping global organizations prepare for the future, the authors sketch multiple long-term scenarios for the biosciences - and reveal how they will impact your health, family, career, society, even the Earth itself.

Full Product Details

Author:   Paul J. H. Schoemaker ,  Joyce A. Schoemaker
Publisher:   Pearson Education (US)
Imprint:   Financial TImes Prentice Hall
Dimensions:   Width: 15.80cm , Height: 1.90cm , Length: 23.40cm
Weight:   0.450kg
ISBN:  

9780137153855

ISBN 10:   0137153856
Pages:   240
Publication Date:   08 October 2009
Audience:   General/trade ,  Adult education ,  General ,  Further / Higher Education
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   In Print  
Limited stock is available. It will be ordered for you and shipped pending supplier's limited stock.

Table of Contents

Foreword xii Preface xiv   Chapter 1 Living well beyond 100   1 Great progress made, much more to come 1 Medical challenges and promises 4 Living well versus living longer 7 Social challenges and promises 10 Can we afford old age? 11 Government and business 13 The journey ahead 17   Chapter 2 A short history of biomedicine   21 Improving hygiene 21 The power of immunology 23                 Monoclonal antibodies 24 The discovery of antibiotics 25 The DNA revolution 26                 Recombinant DNA and cloning 27                 Biotechnology 29 Unraveling the code 31 Conclusion 33   Chapter 3 Snapshot of the biosciences   35 DNA-based technologies 35                 Genomics 37                 Genetic testing 37                 DNA chips 39                 Pharmacogenetics 40                 Cloning 41                 Gene therapy 43 RNA-based technologies 45                 Antisense technology 45                 RNA interference (RNAi) 46 Protein-based technologies 46                 Vaccines 47                 Monoclonal Antibodies 48                 Proteomics 49 Cell-based and other technologies 50                 Stem cells 50                 Antimicrobials 51 Conclusion 52   Chapter 4 Bio-driven convergence   57 Converging technologies 58                 Telemedicine 58                 Remote diagnostics 59                 Biological drug factories 59                 Biochips 59                 Tissue engineering 60                 Imaging 61                 Multidirectional synergies 62                 Shifting industry boundaries 64 Healthcare and IT 65                 Medical information handling 65                 Medical data storage 66                 Computers and drug discovery 66                 Remote monitoring and the wired home 67 Reshaping bioinformatics 67                 Bioinformatics and gene banks 69                 Personalized medicine 70                 Systems biology and holistic medicine 70                 Biosensors 72                 Nano devices 72 Commercialization challenges 73                 Technological challenges: biocompatibility 74                 Regulatory challenges: clinical safety and efficacy 74                 Political challenges: privacy and ownership 74                 Social challenges: consumer advocacy 75 The road ahead 76   Chapter 5 The business of biomedicine   79 The pharmaceutical industry 79                 Diminishing drug pipelines 82 The biotechnology sector 85 Medical device industry 89                 Cardiovascular device segment 89                 Orthopedic device segment 91                 Neurological device segment 91 Medical diagnostics industry 92                 Laboratory testing 93                 Point-of-care (POC) patient monitoring and diagnosis 94 Prevention and disease management 95 Conclusions 97   Chapter 6 Healthcare under stress   101 Stress in developed nations 103                 Healthcare funding 104                 Major diseases of the developed world 105                 Cardiovascular diseases 106                 Cancer  106 Stress in developing nations 107                 Acquired Immune Deficiency Syndrome (AIDS) 109                 Malaria 111 Which technologies will succeed? 113 Illustrative cases 114                 AIDS and malaria 115                 Cardiovascular diseases 115                 Cancer 116   Chapter 7 Wildcards for the future   125 Trends versus uncertainties 125 Wildcards 127 Society and politics 127                 Public support of the biosciences? 127                 A major pandemic? 129                 Biotech rogue states? 130 Science and technology 131                 Raging success or major meltdown? 131                 Role of complementary industries? 132                 Intellectual property regimes? 133                 Qualified staff for healthcare and research? 133 Business and economics  134                 Economic growth and global power shifts? 134                 Venture capital and other funding sources? 135                 Climate change and resource scarcity? 135 A scenario framework 136                 The first overarching uncertainty: technological success 137                 The second overarching uncertainty: societal acceptance 137                 Multiple scenarios are possible 138 The role of stakeholders 141   Chapter 8 Scenarios up to 2025   143 Bio gridlock scenario 143                 The view from 2025 143                 How we got here 145                 The world we live in 150                 Analogous cases 151 Golden age scenario 153                 The view from 2025 154                 How we got here 154                 The world we live in 158                 Analogous case: information technology 160   Chapter 9 What it all means   163 You and your family 163 At work 168 Business and commerce 170 Society at large  172   Appendix A DNA, RNA, and protein   177 Molecules of inheritance 177 The structure of DNA 178 Cracking the code  179 Making proteins 180 Regulating gene expression 181   Appendix B Cloning genes   183 Restriction enzymes 183 Cloning procedure 184   Appendix C Complexity of the genome   187 Non-Coding RNAs 187 SNP variations 188   Glossary of Biomedical Terms   191 Acknowledgments   199 About the Authors   201 Index   203

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Author Information

Paul J. H. Schoemaker, Ph.D. is Research Director of the Mack Center for Technological Innovation at The Wharton School, where he teaches strategy and decision making. Dr. Schoemaker is also the founder and chairman of Decision Strategies International, Inc., a consulting and training firm specializing in strategic planning and executive development. He has written more than 100 academic and applied papers as well as coauthored numerous books, including Decision Traps, Wharton on Managing Emerging Technologies, Winning Decisions, Profiting from Uncertainty, and Peripheral Vision. He serves on multiple boards.   Joyce A. Schoemaker, Ph.D. has conducted basic research in microbiology and molecular genetics at the University of Chicago and taught microbiology at Villanova University. She has held positions in research and management at several biotechnology companies, including Celltech in London, and has published numerous scientific articles in biology. She is coauthor of Healthy Homes, Healthy Kids: Protecting Your Children From Everyday Environmental Hazards. Dr. Schoemaker has a long-standing interest in environmental issues as well as the emerging biosciences.  

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