Overview

Fungal diseases have been with us from antiquity; interest in the chemo­ therapy of fungal disease has exploded in the past decade. To plan and pro­ duce a book on the topic of antifungal chemotherapy has come as a personal challenge - and something of an eye-opener - towards the end of my re­ search career. A landmark publication which still merits reading is Antifungal Chemotherapy (John Wiley & Sons, Chichester, UK), edited by David Speller, which appeared in 1980. However, the fact that ketoconazole, the first of the modern, orally active, wide-spectrum antifungals, attracted no more than two sentences in it indicates just how far we have come in the 1980s. A steady stream of original papers and a number of conference proceedings have chronicled this progress in drug research; outstanding among the latter are the proceedings of an international telesymposium, entitled Recent Trends in the Discovery, Development and Evaluation of Antifungal Agents, edited by Robert Fromtling (J.R. Prous, Barcelona, 1987) and volume 544 of the Annals of the New York Academy of Sciences, entitled Antifungal Drugs, edited by Vassil St. Georgiev, and containing papers and posters presented at a most enjoyable 3-day conference held at Garden City, New York, in the autumn of 1987.

Full Product Details

Author:   John F. Ryley ,  D. Armstrong ,  F.T. Boyle ,  M. Debono
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1990
Volume:   96
Dimensions:   Width: 15.50cm , Height: 3.00cm , Length: 23.50cm
Weight:   0.879kg
ISBN:  

9783642754609

ISBN 10:   3642754600
Pages:   558
Publication Date:   13 December 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Section I. Drug Discovery.- 1 Drug Discovery: A Chemist’s Approach.- 2 Drug Discovery: A Biochemist’s Approach.- 3 Drug Discovery: Nature’s Approach.- 4 Screening and Evaluation In Vitro.- 5 Screening And Evaluation In Vivo.- Section II. Drug Development.- 6 Mode Of Action Studies.- 7 Pharmacokinetic Aspects of Antifungal Therapy.- 8 Hepatic and Endocrine Effects of Azole Antifungal Agents.- 9 Structure-Teratogenicity Relationships Among Antifungal Triazoles.- 10 Formulation.- 11 Regulatory Procedures.- 12 Clinical Trials.- Section III. Clinical Usage.- 13 Clinical Usage — A Dermatologist’s Viewpoint.- 14 Therapeutic Considerations in Fungal Vaginitis.- 15 An Infectious Disease Specialist’s Viewpoint.- 16 Management of Fungal Infections in Patients with Neoplastic Diseases.- 17 Fungal Infections and AIDS.- 18 Older Drugs.- 19 Systemic Azole Antifungal Drugs — Into the 1990s.- 20 Terbinafine.- 21 Amorolfine.- Section IV. Where Next?.- 22 Other Compounds in Development.

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