Overview

The aim of these two volumes on Chemosensitivity is to comprehensively present protocols that can be used to assess chemosensitivity in vitro and in vivo, as well as to assess parameters that modulate chemosensitivity in individual tumors. The volumes, collectively, are divided into four major sections, covering the following topics: In Vitro Measures of Cemosensitivity; Measurements of DNA Damage, Cell Death, and Regulators of Cytotoxicity; Genomics, Proteomics, and Chemosensitivity; and In Vivo Animal Modeling of Chemosensitivity. At the end of each chapter a Notes section is included with useful information, helpful hints, and problems and pitfalls to be aware of.

Full Product Details

Author:   Rosalyn D. Blumenthal
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2005 ed.
Volume:   110
Dimensions:   Width: 15.50cm , Height: 1.50cm , Length: 23.50cm
Weight:   1.160kg
ISBN:  

9781588293459

ISBN 10:   1588293459
Pages:   231
Publication Date:   14 February 2005
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

An Overview of Chemosensitivity Testing.- Clonogenic Cell Survival Assay.- High-Sensitivity Cytotoxicity Assays for Nonadherent Cells.- Sulforhodamine B Assay and Chemosensitivity.- Use of the Differential Staining Cytotoxicity Assay to Predict Chemosensitivity.- Collagen Gel Droplet Culture Method to Examine In Vitro Chemosensitivity.- The MTT Assay to Evaluate Chemosensitivity.- Histoculture Drug Response Assay to Monitor Chemoresponse.- In Vitro Testing of Chemosensitivity in Physiological Hypoxia.- Chemosensitivity Testing Using Microplate Adenosine Triphosphate-Based Luminescence Measurements.- High-Throughput Technology.- Dimscan.- The ChemoFx® Assay.- Evaluating Response to Antineoplastic Drug Combinations in Tissue Culture Models.- Image Analysis Using the Fluorochromasia Assay to Quantify Tumor Drug Sensitivity.- Immunohistochemical Detection of Ornithine Decarboxylase as a Measure of Chemosensitivity Testing.- Immunohistochemistry of p53, Bcl-2, and Ki-67 as Predictors of Chemosensitivity.

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