Overview

Since the early 1990s, the field of oxygen-sensing has evolved from the findings of further oxygen sensing cells both in peripheral and central tissues, of molecules and channels implicated in chemoreception, and of transcriptional factors controlling the expression of a number of genes involved in physiological responses to hypoxia. In order to take into account these new aspects of chemoreception, this volume presents a multidisciplinary approach at the interface of cellular, molecular biology and integrative physiology with the main objective to elucidate the chemosensory processes and associated cardiorespiratory functions in hypoxic/hypercapnic environmental conditions. Specifically, the volume presents up to date major aspects of the chemoreceptor pathway from molecular and cellular signalling processes in the carotid body and other oxygen-sensing structures to central integration of chemosensory inputs and systemic implications. Because sustained changes in oxygen homeostasis are able to induce morphofunctional remodelling which remains poorly understood but may provide further ways of research in physiology and pathophysiology, two sessions were devoted to the mechanisms involved in the processes of plasticity induced by long-term or intermittent hypoxia during the perinatal period or at adulthood.

Full Product Details

Author:   Jean-Marc Pequignot ,  Constancio Gonzalez ,  Colin A. Nurse ,  Nanduri R. Prabhakar
Publisher:   Springer Science+Business Media
Imprint:   Kluwer Academic/Plenum Publishers
Edition:   2003 ed.
Volume:   536
Dimensions:   Width: 17.80cm , Height: 4.50cm , Length: 25.40cm
Weight:   3.190kg
ISBN:  

9780306478680

ISBN 10:   0306478684
Pages:   633
Publication Date:   31 October 2003
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Honoring Pierre Dej ours His Contribution to the Study of the Role of the Arterial Chemoreceptors in the Regulation of Breathing in Humans.- O2 and CO2 Sensing Mechanisms in the Peripheral Arterial Chemoreceptors: Membrane Properties, Intracellular Metabolic and Genomic Events.- O2 and CO2 Sensing Mechanisms in Airway Chemoreceptors, Pulmonary Artery Smooth Muscle Cells and Other Oxygen-sensing Systems: Membrane Properties, Intracellular Metabolic and Genomic Events.- Mechanisms of Communication Between Chemosensory Cells and Chemoafferent Fibers.- Brainstem O2 and CO2 Sensing — Central Integration of Peripheral Chemosensory Inputs.- Plasticity of Chemosensitivity Processes During Development: Transition at Birth and Delayed Effects.- Plasticity of Chemosensitive Processes: Acclimatization to Intermittent Versus Chronic Hypoxia in Adult.

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