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Author:   Hugo Kubinyi ,  Gerhard Muller ,  Raimund Mannhold ,  Gerd Folkers
Publisher:   Wiley-VCH Verlag GmbH
Imprint:   Wiley-VCH Verlag GmbH
Dimensions:   Width: 18.60cm , Height: 2.80cm , Length: 24.60cm
Weight:   1.056kg
ISBN:  

9783527309870

ISBN 10:   352730987
Pages:   487
Publication Date:   06 August 2004
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Awaiting stock  

Table of Contents

Preface. A Personal Foreword. List of Contributors. Introduction (G. Muller & H. Kubinyi). I: GENERAL ASPECTS. 1. Target Family-directed Masterkeys in Chemogenomics (G. Muller). 2. Drug Discovery from Side Effects (H. Kubinyi). 3. The Value of Chemical Genetics in Drug Discovery (K. Russell & W. Michne). 4. Structural Aspects of Binding Site Similarity: A 3D Upgrade for Chemogenomics (A. Bergner & J. Gunther). II: TARGET FAMILIES. 5. The Contribution of Molecular Informatics to Chemogenomics: Knowledge-based Discovery of Biological Targets and Chemical Lead Compounds (E. Jacoby, et al.). 6. Chemical Kinomics (B. Klebl, et al.). 7. Structural Aspects of Kinases and Their Inhibitors (R. Buijsman). 8. A Chemical Genomics Approach for Ion Channel Modulators (K. Baringhaus & G. Hessler). 9. Phosphodiesterase Inhibitors: A Chemogenomic View (M. Hendrix & C. Kallus). 10. Proteochemometrics: A Tool for Modeling the Molecular Interaction Space (J. Wikberg, et al.). III: CHEMICAL LIBRARIES. 11. Some Principles Related to Chemogenomics in Compound Library and Template Design for GPCRs (T. Webb). 12. Computational Filters in Lead Generation: Targeting Drug-like Chemotypes (W. Guba & O. Roche). 13. Navigation in Chemical Space: Ligand-based Design of Focused Compound Libraries (G. Schneider & P. Schneider). 14. Natural Product-derived Combinatorial Libraries and Protein Structure Similarity as Guiding Principles for the Discovery of Drug Candidates (M. Koch & H. Waldmann). 15. Combinatorial Chemistry in the Age of Chemical Genomics (R. Joseph & P. Arya). Index.

Reviews

"""This hallmark text marks a breakthrough in the field...vital to the researcher."" (Electric Review, April/May 2005)"

This hallmark text marks a breakthrough in the field...vital to the researcher. (Electric Review, April/May 2005)

Author Information

"Hugo Kubinyi studied chemistry in Vienna, Austria. After his Ph.D. thesis at the Max Planck Institute of Biochemistry in Munich he continued as a PostDoc at the German Cancer Research Centre in Heidelberg. In 1966 he joined Knoll AG, later a subsidiary of BASF AG, and in 1985 he moved to BASF AG. Since 1987, until his retirement in summer 2001, he was responsible for the Molecular Modelling, Protein Crystallography and Drug Design group of BASF, since early 1998 also for Combinatorial Chemistry in the Life Sciences. He is Professor of Pharmaceutical Chemistry at the University of Heidelberg, former Chair of The QSAR and Modelling Society, and IUPAC Fellow. From his scientific work resulted five books on QSAR, 3D QSAR, and Drug Design (the German book ""Wirkstoffdesign"" received the 1999 Book Award of the FCI, Association of Chemical Industry) and about 90 publications. He is a member of several Scientific Advisory Boards, coeditor of the Wiley-VCH book series ""Methods and Principles in Medicinal Chemistry"", and member of the Editorial Boards of several scientific journals. Gerhard M?ller graduated in Organic Chemistry from the University of Frankfurt/Main (Germany) and received his PhD in 1992 at the Technical University of Munich. After two years in the Medicinal Chemistry department of Glaxo Verona (Italy), he joined the central research facility of the Bayer AG, Leverkusen. From 1998 onwards he was project manager of a target family approach in medicinal chemistry. From 2001 to 2003 he headed the chemistry section of Organon's Lead Discovery Unit in Oss (The Netherlands). Since summer 2003, Gerhard M?ller is the chief scientific officer of the Munich-based biotech company Axxima Pharmaceuticals AG."

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