Overview

During the last 30 years, knowledge of the essential role that pyrrole structures play in the chemistry of living organisms, drug design, and the development of advanced materials has increased. Correspondingly, research on the diverse issues of synthetic, theoretical, and applied chemistry has snowballed. Devoted to the latest achievements of this field, Chemistry of Pyrroles covers the discovery and development of a novel, facile, and highly effective method for the construction of the pyrrole ring from ketones (ketoximes) and acetylene in superbase catalytic systems (Trofimov reaction). It provides cutting-edge details on the preparation of valuable but previously inaccessible pyrrole compounds. It includes approximately 1,000 structures of novel pyrrole compounds, their yields, and physical-chemical characteristics. The authors analyze conditions of typical syntheses, limitations of their applicability, and possibility of vinyl chloride or dichloroethane application instead of acetylene. They examine chemical engineering aspects of the first synthesis of tetrahydroindole and indole from commercially available oxime of cyclohexanone and acetylene. In addition, the book discusses new facets of pyrroles and N-vinyl pyrroles reactivity in the reactions with the participation of both the pyrrole ring and N-vinyl groups. The book provides condensed, clear-cut information on novel syntheses of substituted pyrroles as key structural units of living matter (chlorophyll and hemoglobin), pharmaceuticals, and monomers for optoelectronic materials. It includes tables that provide references to original works, forming a guide to a variety of the reactions and synthesized compounds discussed. With coverage of the broad range of pyrrole chemistry and methods for their synthesis, it provides both a theoretical and an experimental basis for drug design.

Full Product Details

Author:   Boris A. Trofimov (A.E. Favorsky Irkutsk institute of chemistry, Russia) ,  Al'bina I. Mikhaleva (A.E. Favorsky Irkutsk Institute of Chemistry, Russia) ,  Elena Yu Schmidt (A.E. Favorsky Irkutsk Institute of Chemistry, Russia) ,  Lyubov N. Sobenina (A.E. Favorsky Irkutsk Institute of Chemistry, Russia)
Publisher:   Taylor & Francis Ltd
Imprint:   CRC Press
Weight:   0.740kg
ISBN:  

9781138034020

ISBN 10:   1138034029
Pages:   398
Publication Date:   16 November 2016
Audience:   College/higher education ,  General/trade ,  Tertiary & Higher Education ,  General
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Introduction. Synthesis of Pyrroles and N-Vinylpyrroles by the Reaction of Ketones (Ketoximes) with Acetylenes. Heterocyclization of ketoximes with acetylene. Regioselectivity of the reaction. Substituted acetylenes in reactions with ketoximes. Vinyl halogenides and dihalogenethanes as synthetic equivalents of acetylene . Intermediate stages and side reactions. δ-Carbolines from 3-acylindoles and acetylene. Reaction of ketoximes with acetylene in the presence of ketones. One-pot assembly of 4-methylen-3-oxa-1-azabicyclo[3.1.0]hexanes. Transformations of aldoximes in the systems MOH/DMSO and MOH/DMSO/acetylene. Mechanism of pyrrole synthesis from ketoximes and acetylene. Novel Aspects of NH- and N-Vinylpyrroles Reactivity. Reaction with the participation of the pyrrole ring. Reactions with participation of the vinyl group. Conclusions. References. Index.

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Boris A. Trofimov, Al'bina I. Mikhaleva, Elena Yu Schmidt, Lyubov N. Sobenina

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