Overview

This book provides an expert overview on ion channel-related arrhythmia mechanisms, and describes important advances in our understanding of how ion channel dysfunction causes cardiac disease. Both, scientific findings and clinical implications are presented and discussed by scientists who have considerably contributed to the field. The book is organized in three parts: part I  treats the molecular and electrophysiological mechanisms of function and dysfunction of ion channels,  part II focuses on genetics and clinical findings, whereas part III describes novel research techniques, the use of stem cells and animal models and provides an outlook on future investigations and applications. The book is written for scientists in Cardiovascular Biology and Neuroscience and will be of general interest to Medical Doctors in Cardiology, Cardiac Electrophysiology and related disciplines.  

Full Product Details

Author:   Dierk Thomas ,  Carol Ann Remme
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   1st ed. 2018
Volume:   6
Weight:   1.030kg
ISBN:  

9783319778112

ISBN 10:   3319778110
Pages:   439
Publication Date:   24 September 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Introduction.- Part 1: (Dys)function of cardiac ion channels. Cardiac sodium channel (dys)function and inherited arrhythmia syndromes.- Potassium channels in the heart.- Voltage-gated calcium channels and their roles in cardiac electrophysiology.-  HCN channels and cardiac pacemaking.- Dysregulation of ionic homeostasis: relevance for cardiac arrhythmias.- Part 2: Cardiac channelopathies: clinical and genetic findings. Long and short QT syndromes.- Brugada syndrome: current perspectives.- Sinus node disease and cardiac conduction disease.- Catecholaminergic polymorphic ventricular tachycardia.- Idiopathic ventricular fibrillation and early repolarization.- Atrial fibrillation.- Genetic testing for inheritable cardiac channelopathies.- Part 3: Research into cardiac channelopathies: new avenues. Novel imaging techniques in cardiac ion channel research.- Transgenic animal models of cardiac channelopathies – benefits and limitations.- Induced pluripotent stem cell-derived cardiomyocytes: towards personalized therapeutic strategies?.  

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Author Information

Prof. Dr. med. Dierk Thomas is Associate Professor at the University of Heidelberg and Head of the Cardiac Electrophysiology Department, Medical University Hospital, University of Heidelberg, Germany. Dr. Carol Ann Remme is Associate Professor and Principal Investigator at the Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands.

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