Overview

Cerebral amyloid angiopathy (CAA) is a distinctive abnormality of small cerebral blood vessels, one that has intrigued neuroscientists for decades. The time seems right for a book which examines the phenomenon of CAA using a multifaceted approach: What does it produce clinically? How might CAA be imaged? What are the crucial biochemical/cellular events within cerebral vessel walls that lead to CAA? How can in vitro or transgenic experimental systems be used to understand the etiology of, or even potential treatments for, CAA? The editors have assembled key figures in the field of CAA research to examine these (and other) questions in a series of focused chapters that address specific issues of importance in understanding CAA and its clinical manifestations. Comprehending the biology and pathogenesis of this fascinating vascular lesion may even provide clues to less common forms of cerebral microvascular disease that have been recognized for decades (hypertensive microangiopathy) or more recently (CADASIL).

Full Product Details

Author:   M.M. Verbeek ,  R.M. de Waal ,  Harry V. Vinters
Publisher:   Springer
Imprint:   Springer
Edition:   Softcover reprint of hardcover 1st ed. 2000
Dimensions:   Width: 21.00cm , Height: 1.90cm , Length: 27.90cm
Weight:   0.934kg
ISBN:  

9789048154807

ISBN 10:   9048154804
Pages:   358
Publication Date:   01 December 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

Section I: Clinical Aspects of CAA and CAA-Related Hemorrhage.- 1 Clinical aspects and diagnostic criteria of sporadic CAA-related hemorrhage.- 2 Diagnosis of CAA during life. Neuroimaging of CAA.- 3 Vascular risk factors for Alzheimer’s disease. An epidemiologic perspective.- 4 Cerebral microvascular and macrovascular disease in the aging brain; similarities and differences.- Section II: Genetics of CAA.- 5 ApoE genotype in relation to sporadic and Alzheimer-related CAA.- 6 Clinical and genetic aspects of hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D).- 7 Genetics and neuropathology of hereditary cystatin C amyloid angiopathy (HCCAA).- Section III: Cellular and Molecular Pathology of CAA.- 8 Neuropathologic features and grading of Alzheimer-related and sporadic CAA.- 9 Chemical analysis of amyloid ? protein in CAA.- 10 Immunohistochemical analysis of amyloid ? protein isoforms in CAA.- 11 Blood Brain Barrier dysfunction and cerebrovascular degeneration in Alzheimer’s disease.- 12 A?-associated proteins in cerebral amyloid angiopathy.- 13 Neuropathology of hereditary cerebral hemorrhage with amyloidosis-Dutch type.- 14 Neuropathology and genetics of prion protein and British cerebral amyloid angiopathies.- Section IV: In Vitro and Animal Models of CAA.- 15 Amyloid ? protein internalization and production by canine smooth muscle cells.- 16 Degeneration of human cerebrovascular smooth muscle cells and pericytes caused by amyloid ? protein.- 17 Vasoactivity of amyloid ? peptides.- 18 CAA in transgenic mouse models of Alzheimer’s disease. What can we learn from APP transgenic mouse models?.- 19 Cerebral amyloid angiopathy in aged dogs and nonhuman primates.- 20 Vascular transport of Alzheimer’s amyloid ? peptides and apolipoproteins.

Reviews

'Meantime, this book offers good value for money for those clinicians and scientists interested in the current state of play.' Brain, 124 (2001)

'Meantime, this book offers good value for money for those clinicians and scientists interested in the current state of play.' Brain, 124 (2001)

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions