Overview

As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimited cell proliferation, is attracting considerable interest because of its links to tumor suppression.

Full Product Details

Author:   Peter D. Adams ,  John M. Sedivy
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2010 ed.
Dimensions:   Width: 15.50cm , Height: 2.00cm , Length: 23.50cm
Weight:   0.653kg
ISBN:  

9781441910745

ISBN 10:   1441910743
Pages:   272
Publication Date:   17 December 2009
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

Table of Contents

Introduction: J Sedivy. Section 1. Senescence signals. 1. Telomere biology and biochemistry: 1, J Karlseder; 2, T de Lange; 3, L Harrington. 2. Short telomere-driven senescence: 1, F d'Adda di Fagagna; 2, N Sharpless; 3, V Bohr. 3. Oncogene-induced senescence: 1, M Serrano; 2, J Bartek; 3, G, Ferbeyre. 4. Stress-induced senescence: 1, T Finkel; 2, V Gorbunova; 3, E Hara; 4, F Ishikawa. 5. Modulation of senescence by extracellular growth factors: 1, P Adams. Section 2. The senescent phenotype. 6. The senescent phenotype and its evolution: 1, J Campisi. 7. Chromatin structure in senescent cells: 1, E Medrano; 2. M Narita. 8. A comparison of senescence in mouse and human cells: 1, C Greider; 2, M Blasco. Section 3. The physiological consequences of senescence. 9. Tumor suppression: 1, G Peters; 2, N Sharpless; 3, S Chang. 10. Tissue aging: 1, L Rudolph; 2, A Trumpp. 11. Senescence as a potential therapeutic tool: 1, C Schmitt; 2, S Lowe.

Reviews

Author Information

Tab Content 6

Author Website:  

Countries Available

All regions