Cellular Senescence and Tumor Suppression
Author:   Peter D. Adams ,  John M. Sedivy
Publisher:   Springer-Verlag New York Inc.
Edition:   2010 ed.
ISBN:  

9781489983565


Pages:   272
Publication Date:   30 November 2014
Format:   Paperback
Availability:   Manufactured on demand   Availability explained
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Cellular Senescence and Tumor Suppression


Overview

As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimited cell proliferation, is attracting considerable interest because of its links to tumor suppression.

Full Product Details

Author:   Peter D. Adams ,  John M. Sedivy
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2010 ed.
Dimensions:   Width: 15.50cm , Height: 1.50cm , Length: 23.50cm
Weight:   0.444kg
ISBN:  

9781489983565


ISBN 10:   1489983562
Pages:   272
Publication Date:   30 November 2014
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Senescence signals.- Telomere Biology and Biochemistry.- Role of RecQ Helicases in Nuclear DNA Repair and Telomere Maintenance.- Oncogene-Induced Senescence (OIS) as a Cellular Response to Oncogenic Stresses.- Stress-Induced Senescence.- The senescent phenotype.- The Secretome of Senescent Cells.- Chromatin Structure in Senescent Cells.- A Comparison of Senescence in Mouse and Human Cells.- The physiological consequences of senescence.- Replicative Senescence as an Intrinsic Tumor-Suppressor Mechanism.- Telomere Dysfunction and Senescence in Stem Cell and Tissues Aging.- Mining Cellular Senescence for Drug Targets.

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