Overview

Cellular Lipid in Health and Disease presents a comprehensive and systematic coverage of the various roles lipids play in human biology. This book is organized around the key roles lipids play in cellular biology, both in health and disease states. The first group of chapters is dedicated to the basic concepts of cellular lipids and the roles it plays in the cell, structure and physiology, storage, and utilization. The next set of chapters is focused on lipid metabolism, covering the organelles involved in lipid trafficking, cholesterol homeostasis, autophagy signaling, and metabolism in aging. The final group of chapters is dedicated to roles lipids play in specific disease states including diabetes, chronic kidney disease complications, obesity, heart diseases, nonalcoholic fatty liver disease, colorectal cancer, neurodegenerative diseases, B cell immunity, inflammation, viral infections, and other metabolic diseases. Cellular Lipid in Health and Disease is a complete reference targeted at graduate students and early career researchers in cell biology, biochemistry, and pharmacology. Research physicians can also benefit from the foundational content and links to pathologies and therapeutic opportunities.

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Dr. James M. Ntambi is a Professor of Biochemistry and the Steenbock Professor of Nutritional Sciences, at the University of Wisconsin-Madison, as well as an Adjunct Professor of Biological Chemistry at Johns Hopkins University School of Medicine. The focus of Dr. Ntambi’s research is to understand the genetic regulation of metabolism, adipocyte biology, and differentiation. He is specifically interested in the genetic basis of obesity, cardiovascular disease, insulin resistance, and diabetes and how dietary factors, hormones, and environmental factors influence these disease states. Recently, his team has genetically engineered mice that are born without the stearoyl-CoA desaturase gene-1, and found that these mice resist obesity, diabetes, and fatty liver disease. Most recent work has focused on the role monounsaturated fatty acids in diet induced de novo lipogenesis, obesity, and insulin resistance. Dr. Ntambi also conducts research on obesity and diabetes and other noncommunicable metabolic diseases in developing countries. Dr. Ntambi has published more than 230 scientific articles in such journals including Journal of Biological Chemistry, Journal of Lipid Research, PNAS, Science, Cell Metabolism, Hepatology journal, BBRC, JCI, BBA, PLoS, Journal of Nutrition, and American Journal of Physiology-Endocrinology and Metabolism, among others.

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