Overview

Global health has been challenged with the dawning of the era of the obesity epidemic, and thus as a consequence, strategies to reduce obesity have become public health priorities. According to the United Nations, obesity has been identified as a concern for achieving Sustainable Development Goals. Obesity is a serious health problem with an increased risk of several common diseases including diabetes, cardiovascular disease, and cancer. Although the fundamental cause of obesity and overweight is an imbalance between calorie intake and calorie expenditure, the underlying biochemical and metabolic processes that cause obesity are not fully understood. Two earlier volumes dedicated to the subject of obesity, published in the series “Advances in Biochemistry in Health and Disease” focused on the pathophysiology of obesity-induced health complications and the biochemistry of cardiovascular dysfunction in obesity. This book brings together contributions from international experts in the field to describe advancements on the mechanisms leading to development of obesity and related complications. There are 21 chapters in two different parts in this book, comprising of Part I: Pathophysiologic Mechanisms of Obesity (11 chapters) and Part II: Therapeutic Mechanisms of Obesity (10 chapters).  This book will serve as a resource and be of interest to health professionals, medical students, fellows, residents and graduate students. It will also evoke innovative research and effective approaches for the prevention of obesity. This volume will accentuate that obesity is a major health hazard in its own right and that appropriate public health measures should be implemented to prevent or reduce or even reverse the impact of this global chronic disease.   

Full Product Details

Author:   Paramjit S. Tappia ,  Bram Ramjiawan ,  Naranjan S. Dhalla
Publisher:   Springer Nature Switzerland AG
Imprint:   Springer Nature Switzerland AG
Edition:   1st ed. 2021
Volume:   23
Weight:   0.658kg
ISBN:  

9783030847654

ISBN 10:   3030847659
Pages:   414
Publication Date:   17 December 2022
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

A. INTRODUCTIONParamjit S. Tappia, Bram Ramjiawan, Naranjan S. DhallaAsper Clinical Research Institute, St. Boniface HospitalCR3129-369 Tache AvenueWinnipeg, Manitoba, Canada R2H 2A6Email: ptappia@sbrc.caTitle: Cellular and biochemical mechanisms of obesity B. Inflammation/cytokines1. Oreste GualilloSERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), The NEIRID Group (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Santiago University Clinical Hospital, Building C, Travesía da Choupana S/N, Santiago de Compostela 15706, Spain.Email: oreste.gualillo@sergas.esTitle: The role of inflammation in obesity2. Kyoungho SukDepartment of Pharmacology, Brain Science & Engineering Institute, Department of Biomedical Science, BK21 PLUS KNU Biomedical Convergence Program, Kyungpook National University School of Medicine, Daegu, Republic of Korea.Email: ksuk@knu.ac.krTitle: Hypothalamic inflammation and malfunctioning glia in the pathophysiology of obesity3. Jennifer M. MonkDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, CanadaEmail: jmonk02@uoguelph.caTitle: The role of the inflammasome in obesity4. Geert van LooVIB Center for Inflammation Research, B-9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium.Email: geert.vanloo@irc.vib-ugent.beTitle: Adipose tissue macrophages and their polarization in health and obesity5. Sonia CaprioDepartment of Pediatric Endocrinology, Yale University School of Medicine, New Haven, Connecticut.Email: sonia.caprio@yale.eduTitle: Adolescent Obesity and Insulin Resistance: Roles of Ectopic Fat Accumulation and Adipose Inflammation6. Giulia MauriziClinica di Ematologia, Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ancona, Italy.Email: g.maurizi@univpm.itTitle: The interplay between adipocytes and immune system cells in the pathophysiology of obesityC. Hormonal imbalances1. Agatha A. van der KlaauwDepartment of Clinical Biochemistry, Metabolic Research Laboratories - Institute of Metabolic Science, University of Cambridge, Cambridge, England.Email: av330@medschl.cam.ac.ukTitle: Neuropeptides in Obesity and Metabolic Disease2. Heather Roff, Colette JappyDonor Network West, 12667 Alcosta Boulevard #500, San Ramon, CA 94583; Kaiser Permanente, Redwood City, CA.Email: Hroff11@gmail.com; colette.jappy@gmail.comTitle: Adiposity and the Role of Neuroendocrine Hormones in Energy Balance3. Jarosław KozakowskiDepartment of Endocrinology, Centre of Postgraduate Medical Education, Bielański Hospital, 80 Cegłowska St., 01-809 Warsaw, PolandEmail: jkozakowski@cmkp.edu.plTitle: Obesity in menopause4. Brigitte LeenersDivision of Reproductive Endocrinology, University Hospital Zurich, Frauenklinikstr. 10, CH 8091 Zurich, Switzerland. Center for Integrative Human Physiology (ZIHP), University of Zurich, 8057 Zurich, Switzerland.Email: Brigitte.Leeners@usz.chTitle: Ovarian hormones and obesity5. Shiying ShaoDivision of Endocrinology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, P.R. China.Email: shaoshiying@hotmail.comTitle: The role of tissue-specific glucocorticoids in central obesity6. D. do Nascimento Marreiro665 Ed. Palazzo Reale, Hugo Napoleão St. apt 2001 Jóquei Teresina, PiauíBrazil 64048320.Email: dilina.marreiro@gmail.comTitle: Thyroid function in obesity7. Terry HindsCenter for Hypertension and Personalized Medicine, University of Toledo College of Medicine, Toledo, Ohio.Email: Terry.Hinds@utoledo.eduTitle: Glucocorticoid hormones: cause or cure for obesity8. Asit Ranjan GhoshCentre for Infectious Diseases and Control, School of BioSciences and Technology, VIT University, Vellore, 632014, Tamil Nadu, India.Email: asitranjanghosh@vit.ac.inTitle: Obesity: An overview of possible role(s) of gut hormones, lipid sensing and gut microbiota9. Anna GavrieliDivision of Endocrinology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Stoneman 820, Boston, MA 02215.Email: agavriel@bidmc.harvard.eduTitle: Recent advances in leptin and obesity10. James R. SowersBurns, Diabetes and Cardiovascular Center, University of Missouri, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO, USA.Email: sowersj@health.missouri.eduTitle: Pathophysiology of obesity due to neurohormonal dysregulation and autophagyD. Autonomic nervous system1. Rosa Maria BrunoDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.Email: rosamaria.bruno@unipi.itTitle: The Role of the Autonomic Nervous System in the Pathophysiology of Obesity2. Hideki KatagiriDivision of Advanced Therapeutics for Metabolic Diseases, Center for Translational and Advanced Animal Research, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.Email: katagiri@mail.tains.tohoku.ac.jpTitle: Disturbance of neuronal signals in the pathophysiology of obesity3. Ana I. DomingosObesity Laboratory, Instituto Gulbenkian de Ciência, Oeiras, Portugal.Email: dominan@igc.gulbenkian.ptTitle: The sympathetic neuro-adipose connection and the control of body weight4. Gino SaravalleCardiology Department, S. Luca Hospital, Istituto Auxologico Italiano, Piazza Brescia 20, 20149, Milan, Italy.Email: g_seravalle@yahoo.comTitle: Sympathetic activation in obesity5 Zhengtang Qi, Shuzhe DingCollege of Physical Education and Health, East China Normal University, 500 Dongchuan Road, 200241 Shanghai, P.R. China,Email: qzht79@163.comTitle: Obesity-associated sympathetic overactivity in children and adolescents: the role of catecholamine resistance in lipid metabolism6. Markus P. SchlaichNeurovascular Hypertension and Kidney Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, VIC 3004, Australia.Email: markus.schlaich@uwa.edu.auTitle: Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic Syndrome7. Elisabeth A. LambertBaker IDI Heart & Diabetes Inst., PO Box 6492, St. Kilda Rd. Central, Melbourne, Victoria, 8008, Australia.Email: elisabeth.lambert@bakeridi.edu.auTitle: Should the sympathetic nervous system be a target to improve obesity?E. Oxidative stress1. Alice CarrierCNRS, INSERM, Institut Paoli-Calmettes, CRCM, Aix Marseille University , Marseille, France.Email: alice.carrier@inserm.frTitle: Metabolic Syndrome and Oxidative Stress: A Complex Relationship2. Sushil K. JainDepartment of Pediatrics, LSU Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71103,Email: sjain@lsuhsc.eduTitle: The role of oxidative stress in the pathogenesis of obesity3. Ashok K. GroverDepartment of Medicine, HSC 4N41, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1. Canada.Email: groverak@mcmaster.caTitle: How effective are antioxidant supplements in obesity4. Lucia MarsegliaNeonatal and Pediatric Intensive Care Unit, Department of Pediatrics, University of Messina, Via Consolare Valeria 1, 98125 Messina, Italy.Email: lmarseglia@unime.itTitle: Oxidative stress in obesity: a critical component in human diseases5. Norma L. Gomez-ViquezDepartamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados- Instituto Politécnico Nacional, Mexico City, Mexico.Email: letyviquez@hotmail.comTitle: Cellular mechanisms involved in the pathophysiology of obesity during oxidative stress6. Ramaroson AndriantsitohainaDepartment of Biochemistry, Université d'Angers, CHU Angers, 4 rue Larrey, 49933 Angers Cedex 9, France.Email: ramaroson.andriantsitohaina@univ-angers.frTitle: Oxidative stress and metabolic pathologies: from an adipocentric point of view7. Dominique Bonnefont-RousselotService de Biochimie Metabolique, Groupe hospitalier Pitie-Salpetriere (Assistance Publique - Hopitaux de Paris), 47-83 boulevard de l'Hopital, 75651 Paris Cedex 13, France.Email: dominique.rousselot@psl.aphp.frTitle: Oxidative stress contributes to the pathogenesis of obesity8. Concepcion M. AguileraDepartment of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, Centre for Biomedical Research, University of Granada, 18100 Armilla, Granada, Spain.Email: caguiler@ugr.esTitle: The genetics of oxidative stress in obesity9. Morihiro MatsudaInstitute of Clinical Research, National Hospital Organization, Kure Medical Center, and Chugoku Cancer Center, Hiroshima, Japan.Email: morihiro-m@kure-nh.go.jpTitle: Increased oxidative stress is associated with adipocyte fat accumulation10. Atilla EnginFaculty of Medicine, Department of General Surgery, Gazi University, Besevler, Ankara, Turkey.Email: dr.aengin@gmail.comTitle: The vicious cycle of oxidative stress and obesityF. Signal Transduction/sensors and regulators of metabolic status1. Thue W. SchwartzSection for Metabolic Receptology, Novo Nordisk Foundation Center for Basic Metabolic Research, Laboratory for Molecular Pharmacology, Department for Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.Email: tws@sund.ku.dkTitle: GPCR-Mediated Signaling of Metabolites in the pathophysiology of obesity2. Laura HerreroDepartment of Biochemistry and Physiology, School of Pharmacy, Institut de Biomedicina, Universitat de Barcelona, Barcelona, Spain.Email: lherrero@ub.eduTitle: Ceramide signaling in obesity3. Kalyana.NandipatiDepartment of Surgery, Creighton University School of Medicine, 601 N. 30th Street, Suite # 3700, Omaha, NE, 68131, USA.Email: Kalyana.Nandipati@alegent.orgTitle: The role of the triggering receptor in the pathophysiology of obesity4. Pedro BullonDepartment of Oral Medicine and Periodontology, Dental School, University of Seville,C/Avicena s/n, Seville, 41009, Spain.Email: pbullon@us.esTitle: The AMPK pathway in the development of obesity5. Andrew MurphyHaematopoiesis and Leukocyte Biology, Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, 3004, Australia.Email: andrew.murphy@bakeridi.edu.auTitle: Interleukin-1 superfamily: Divergent roles in obesity6. Y.-X. TaoDepartment of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA.Email: taoyaxi@auburn.eduTitle: Ghrelin Receptor Mutations and Human ObesityJongsook Kim KemperUniversity of Illinois at Urbana-Champaign, Urbana, IL, United States.Email: jongsook@illinois.eduTitle: Sirtuin 1 deacetylase: a key regulator of hepatic lipid metabolism8. Daniel J. GoughHudson Institute of Medical Research, 27‐31 Wright Street, Clayton, Victoria 3168, Australia.Email: daniel.gough@hudson.org.auTitle: JAK/STAT signaling pathway in the development of obesity9. Long T. NguyenKolling Institute, Level 9, Royal North Shore Hospital, St. Leonard, NSW 2065, Australia.Email: lngu8923@uni.sydney.edu.auTitle: SIRT1 and SIRT3 as mediators for the development of obesity10. Tsutomu SasakiLaboratory for Metabolic Signaling, Institute for Molecular and Cellular Regulation, Gunma University, 3-39-15 Showa-machi, Maebashi, Gunma 371-8512, Japan.Email: tsutomus@gunma-u.ac.jpTitle: Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity11. Peter ArnerLipid Laboratory, Department of Medicine Huddinge, Karolinska Institutet, SE-141 86 Stockholm, Sweden.Email: peter.arner@ki.seTitle: Interplay between Obesity and cGMP Signaling in adipose tissue

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