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Author:   Suresh I.S. Rattan ,  Leonard Hayflick
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   1st ed. 2016
Volume:   4
Dimensions:   Width: 15.50cm , Height: 2.20cm , Length: 23.50cm
Weight:   6.801kg
ISBN:  

9783319262376

ISBN 10:   3319262378
Pages:   364
Publication Date:   17 May 2016
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Preface.- Section I  History and origins.-  Origins of the Hayflick system, the phenomenon and the limit.- Early testing and development of the Hayflick system.- Section II Serial passaging and progressive changes.- Slowing down of the cell cycle.- Ageing of cells in the centenarians and long-lived .- Aging of the stem cells.- Aging and senescence in the immune cells in vitro and in vivo.- Accelerated cellular aging in progeroid syndromes.- Telomere and genomic instability.- Mechanistic explanation for cellular aging in vitro: the commitment theory.- Modelling cellular aging senescence.- Section-III Regulation, and senescence.- Cell cycle checkpoints and regulators of senescence.- Oxidative stress and cellular ageing.- Biomarkers of replicative senescence revisited.- Cellular aging and tumour regulation.- Declining Protein turnover and degradation.- Section IV Modulating the system.- Stress induced premature senescence (SIPS).- Mild stress-induced hormesis.- Food, hormones and growth factors in cellular aging.- sncRNAs in cellular aging and senescence.- Elimination of senescent cells for rejuvenation.- Section-V RECAPITULATION.- The past, present and the future of cellular aging and replicative senescence.- Index.

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