Cell Motility in Cancer Invasion and Metastasis
Author:   Alan Wells
Publisher:   Springer
Edition:   Softcover reprint of hardcover 1st ed. 2006
Volume:   8
ISBN:  

9789048170111


Pages:   353
Publication Date:   20 November 2010
Format:   Paperback
Availability:   Manufactured on demand   Availability explained
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Cell Motility in Cancer Invasion and Metastasis


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Overview

Cancer Morbidity and mortality result from invasive and metastatic spread. Currently, no therapies are aimed at the underlying mechanisms that enable this progression due to only nascent recognition of the distinct biology which occurs only during tumor dissemination. Recent advances have highlighted the central role of cell motility during the dynamic and transient process of tumor invasion and metastasis. This book includes state-of-the-art updates by international leaders in these studies. Chapters first present the novel model systems that enable new investigations and insights. Chapters then describe in depth the key processes and molecules that may be therapeutically targeted. Finally, the role of cell motility and its signals is explored in a number of key tumor types. This compilation should be useful to researchers in basic and translational oncology as well as those developing novel agents to prevent tumor invasion and metastasis.

Full Product Details

Author:   Alan Wells
Publisher:   Springer
Imprint:   Springer
Edition:   Softcover reprint of hardcover 1st ed. 2006
Volume:   8
Weight:   0.588kg
ISBN:  

9789048170111


ISBN 10:   9048170117
Pages:   353
Publication Date:   20 November 2010
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Motility in Tumor Invasion and Metastasis — An Overview.- In Vitro Matrices for Studying Tumor Cell Invasion.- Imaging Invasion and Metastasis In Vivo.- Imaging Invasion and Metastasis Ex Vivo.- Autocrine Growth Factor Signaling in Motility.- Scatter Factors in Tumor Progression.- Matrix Metalloproteinases in Tumor Progression.- Dynamic Functions of the ?6?4 Integrin in Carcinoma.- Rho GTpases in Cell Motility and Tumorigenesis.- Glioblastoma Cell Motility: The Role of FAK and Cellular SRC.- Motility in Head and Neck Carcinoma.- Motility in Melanoma Progression.- Cell Motility in Prostate Tumor Invasion and Metastasis.

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