Overview

This text introduces the reader to a range of techniques involved in the use of in vitro cell culture in toxicological studies. It deals with all the major cell types studied in the field of toxicology and should be useful for anyone wishing to start work with animal cell cultures or to refresh their knowledge relating to in vitro cell models. Fundamental chapters deal with the general biology of cytotoxicity and these are key issues for in vitro systems addressing the ""3Rs"" principle. Up-to-date overviews deal with the use of cells from liver, brain, skin, and intestine. In addition, biochemical analysis of cell responses, biotransformation pathways in cells and recombinant approaches to the early detection of cell stress are also covered in detail. Prominent features of in vitro technologies also include regulation, biosafety, and standardisation. Dedicated chapters deal with these issues in a practical way in order to lead the reader to the right source of information. This book provides an up-to-date, informative and practical review of cell culture methods for in vitro toxicology.

Full Product Details

Author:   G. Stacey ,  Alan Doyle ,  Margherita Ferro
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Reprinted from CELL BIOLOGY AND TOXICOLOGY, 17:4-5, 2002
Dimensions:   Width: 15.50cm , Height: 1.10cm , Length: 23.50cm
Weight:   0.920kg
ISBN:  

9781402004278

ISBN 10:   1402004273
Pages:   153
Publication Date:   31 December 2001
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

1 Standardisation for In Vitro Toxicity Test.- 2 Application of Cell Cultures to Toxicology.- 3 Immortalisation of Primary Cells.- 4 Safety Considerations for In Vitro Toxicology Testing.- 5 The Drug Metabolizing Enzymatic System and the Experimental Tools Used for In Vitro Toxicology for Metabolic Studies.- 6 Cell Culture models for Hepatotoxicology.- 7 Intestinal Cell Culture Models: Applications of Toxicology and Pharmacology.- 8 Cell Culture Models for Neurotoxicology.- 9 Recombinant Cell Lines for Stress Reporter Assays.

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