Overview

The type of communication between a cell and its immediate environment defines, to a large extent, the phenotype of that cell; it also determines the structure and function of the tissues and organs of which the cell is a part. This book describes the methods essential to the identification and characterization of the molecules that mediate cellular interactions in a variety of systems. Included are methods for preparing relevant probes, analyzing adhesive and junctional interactions in multicellular organizations, determining which structural features of a relevant molecule are functionally important, and for assaying the consequences of cell-cell interactions in cell culture. ""Cell-cell Culture"" aims to provide practical information relating to this area of cell biology. This book should therefore be useful to a range of biological scientists wishing to investigate the mechanisms and consequences of cellular interactions in their system of choice.

Full Product Details

Author:   Bruce R. Stevenson ,  W. J. Gallin ,  D. L. Paul ,  D. L. Paul (Department of Anatomy and Cell Biology, Harvard Medical School, USA)
Publisher:   Oxford University Press
Imprint:   Oxford University Press
Volume:   No. 107
Dimensions:   Width: 15.00cm , Height: 2.60cm , Length: 23.00cm
Weight:   0.729kg
ISBN:  

9780199633197

ISBN 10:   0199633193
Pages:   324
Publication Date:   01 November 1992
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Paperback
Publisher's Status:   Active
Availability:   To order  
Stock availability from the supplier is unknown. We will order it for you and ship this item to you once it is received by us.

Table of Contents

"Assays of cell adhesion, S. Hofman; generation and characterization of function-blocking anti-cell adhesion molecule antibodies, Ann Acheson and Warren Gallin; expression cloning - transient expression and rescue from mammalian cells, Alejandro Aroffo; functional analysis of uvomorulin by site-directed mutagenesis and gene transfer into eukaryotic cells, Jorg Stappert and Rolf Kemler; integrin mutagenesis, A. Reszka and A. Horwitz; isolation of intercellular junctions, Elliot L. Hertzberg et al; the ""Xenopus"" oocyte cell-cell channel assay for functional analysis of gap junction proteins, Gerhard Dahl; patch-clamp analysis of gap junction currents, R.D. Veenstra and P.R. Brink; biochemical approaches for analyzing ""de novo"" assembly of epithelial junctional components, Manijeh Pasdar; biochemical methods for studying supramolecular complexes involving cell adhesion molecules, integral membrane proteins, and the cytoskeleton, W. James Nelson et al; electrophysiological assessment of epithelia, Karl J. Karnaky, Jr; compartmented culture analysis of nerve growth, Robert B. Campenot."

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