Overview

Reader-friendly Cell Biology, 4th Edition, provides a concise but comprehensive foundation for students entering research or health care career paths. Award winning illustrations help readers quickly grasp general principles. The authors have thoroughly updated this popular text to provide readers with the current understanding of the principles of normal cellular function along with examples of how molecular defects predispose to human disease. Major new themes in the 4th edition include the roles of intrinsically disordered polypeptides and phase separation in cellular functions, the influence of new molecular structures on understanding mechanisms, and the impact of exciting new methods-from single cell RNA sequencing to second generation super resolution fluorescence microscopy-on advancing our understanding.  Clear, readable explanations provide a concise story about how cells function at the molecular level.     An intuitive chapter flow starts with genome organization, gene expression, and RNA processing as a foundation for understanding every aspect of cellular function and physiology.  Brings cellular biology to life for students interested in medical science by explaining how mutations in genes can compromise virtually every cellular system and predispose to human disease. Knowledge of cell biology has led to new treatments for cancer, heart failure, cystic fibrosis, and many other diseases.  Unique illustrations with realistic proportions and relationships explain every cellular process including the assembly of SARS CoV-2, the structures attaching mitotic chromosomes to microtubules, the mechanism of DNA replication and how pumps, carriers and channels orchestrate physiological processes from synaptic transmission to cellular volume regulation.  Covers exciting breakthroughs such as SMC motor proteins actively organizing chromosomal DNA, TOR kinases regulating metabolism, new types of immunotherapy for cancer treatment, mechanisms regulating fast axonal transport and their relation to neurodegenerative diseases, how completion of DNA replication sets the time for cells to enter mitosis, how a cascade of signals specifies the site of cell division, and newly understood pathways of normal and pathological cell death.  Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. 

Full Product Details

Author:   Thomas D. Pollard (Sterling Professor, Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT) ,  William C. Earnshaw (Professor and Wellcome Trust Principal Research Fellow, Wellcome Trust Centre for Cell Biology, ICB, University of Edinburgh, Scotland, United Kingdom) ,  Jennifer Lippincott-Schwartz (Group Leader, Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, Virginia, United States) ,  Graham Johnson (Director, Animated Cell, Allen Institute for Cell Biology, Seattle, Washington;, QB3 Faculty Fellow, University of California, San Francisco, San Francisco, California)
Publisher:   Elsevier - Health Sciences Division
Imprint:   Elsevier - Health Sciences Division
Edition:   4th edition
Weight:   2.110kg
ISBN:  

9780323758000

ISBN 10:   0323758002
Pages:   944
Publication Date:   28 February 2023
Audience:   College/higher education ,  Tertiary & Higher Education
Replaced By:   9780323341264
Format:   Hardback
Publisher's Status:   Active
Availability:   In stock  
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Table of Contents

Section I Introduction to Cell Biology 1.Introduction to Cells 2.Evolution of Life on Earth Section II Chemical and Physical Background 3.Molecules: Structures and Dynamics 4.Biophysical Principles 5.Macromolecular Assembly 6.Research Strategies Section III Chromatin, Chromosomes, and the Cell Nucleus 7.Chromosome Organization 8.DNA Packaging in Chromatin and Chromosomes 9.Nuclear Structure and Dynamics Section IV Central Dogma: From Gene to Protein 10.Gene Expression 11.Eukaryotic RNA Processing 12.Protein Synthesis and Folding Section V Membrane Structure and Function 13.Membrane Structure and Dynamics 14.Membrane Pumps 15.Membrane Carriers 16.Membrane Channels 17.Membrane Physiology Section VI Cellular Organelles and Membrane Trafficking 18.Posttranslational Targeting of Proteins 19.Mitochondria, Chloroplasts, Peroxisomes 20.Endoplasmic Reticulum 21.Secretory Membrane System and Golgi Apparatus 22.Endocytosis and the Endosomal Membrane System 23.Processing and Degradation of Cellular Components Section VII Signaling Mechanisms 24.Plasma Membrane Receptors 25.Protein Hardware for Signaling 26.Second Messengers 27.Integration of Signals Section VIII Cellular Adhesion and the Extracellular Matrix 28.Cells of the Extracellular Matrix and Immune System 29.Extracellular Matrix Molecules 30.Cellular Adhesion 31.Intercellular Junctions 32.Connective Tissues Section IX Cytoskeleton and Cellular Motility 33.Actin and Actin-Binding Proteins 34.Microtubules and Centrosomes 35.Intermediate Filaments 36.Motor Proteins 37.Intracellular Motility 38.Cellular Motility 39.Muscles Section X Cell Cycle 40.Introduction to the Cell Cycle 41.G1 Phase and Regulation of Cell Proliferation 42.S Phase and DNA Replication 43.G2 Phase, Responses to DNA Damage, and Control of Entry Into Mitosis 44.Mitosis and Cytokinesis 45.Meiosis 46.Programmed Cell Death Appendix Cell SnapShots

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Author Information

Thomas Dean Pollard is a prominent educator, cell biologist and biophysicist whose research focuses on understanding cell motility through the study of actin filaments and myosin motors. He is Sterling Professor of Molecular, Cellular & Developmental Biology and a Professor of Cell Biology and Molecular Biophysics & Biochemistry at Yale University. He was Dean of Yale's Graduate School of Arts and Sciences from 2010 to 2014, and President of the Salk Institute for Biological Studies from 1996 to 2001. Pollard is very active in promoting scientific education and research primarily through two major societies, both of which he is a past President: the American Society for Cell Biology and the Biophysical Society William Charles Earnshaw is Professor of Chromosome Dynamics at the University of Edinburgh where he has been a Wellcome Trust Principal Research Fellow since 1996. Earnshaw is an elected Fellow of the Royal Society since 2013 for his studies of mitotic chromosome structure and segregation. Before Edinburgh, he was Professor of Cell Biology and Anatomy at Johns Hopkins School of Medicine. Jennifer Lippincott-Swartz is Group Leader at the Howard Hughes Medical Institute Janelia Research Campus. Her lab uses live cell imaging approaches to analyze the spatio-temporal behaviour and dynamic interactions of molecules in cells with a special focus on neurobiology. Before Janelia, Lippincott-Swartz was a primary investigator and chief of the Section on Organelle Biology in the Cell Biology and Metabolism Branch. Her work there included a collaboration with physicists Eric Betzig and Harald Hess (now group leaders at Janelia), who proposed a new function for the photoactivatable protein. The scientists used the protein to generate photoactivatable fluorophores, or dyes, which enabled them to illuminate different sets of molecules sequentially, creating a microscope image far more detailed than previously possible. The method, called super-resolution microscopy, garnered Betzig the 2014 Nobel Prize in Chemistry. Graham Johnson is a computational biologist and Certified Medical Illustrator (CMI) with approx. 20 years of professional experience. He is Director of the Animated Cell at the Allen Institute. Before the Allen Institute, Johnson's lab in the California Institute for Quantitative Biosciences at the University of California, San Francisco worked to generate, simulate and visualize molecular models of cells. His lab's Mesoscope project and his team at Allen Institute continue this mission by uniting biologists, programmers and artists to interoperate the computational tools of science and art.

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