Overview

This volume covers advances in a rapidly expanding field. This area of science has enabled scientists to shed new light on evolution, development, sensory cell function and hereditary deafness on a gene and molecular level, and to apply these techniques to the understanding of the pathogenesis, prevention and cure of ear disorders. The advent of rapid advancements in cell and molecular biology and genetics is making a major impact in biomedicine and these advances will certainly offer unprecedented opportunities in making new progress in otology. Each chapter is intended to cover reviews on the status of selected areas in mechanoreceptor evolution, developmental biology of the ear, structure and function of the auditory sensory cells, innovative approaches for sensory cell protection, inner ear sensory cell regeneration, and gene-based therapy for sensorineural hearing loss.

Full Product Details

Author:   David J. Lim ,  Janet Stoeckert
Publisher:   Springer Science+Business Media
Imprint:   Kluwer Academic/Plenum Publishers
Edition:   2000 ed.
Dimensions:   Width: 17.80cm , Height: 1.70cm , Length: 25.40cm
Weight:   1.760kg
ISBN:  

9780306463747

ISBN 10:   0306463741
Pages:   267
Publication Date:   31 January 2001
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

I. Mechanoreceptor Biology.- 1. Kinociliary Mechanoreceptors in the Equilibrium Receptor Organs of Cephalopods.- 2. Stereocilia Based Mechanoreceptors of Sea Anemones.- 3. Plasma Membrane Ca2+-ATPase and Hair-Cell Function.- 4. Molecular Determinants of Hair Cell Phenotypic Heterogeneity—Differential Expression of K Channel Genes.- 5. Structural Basis of Outer Hair Cell Motility or Where’s the Motor?.- II. Developmental Biology of the Ear.- 6. Induction of Ectodermal Placodes.- 7. Compartments and Boundaries in the Developing Inner Ear.- 8. Role of the POU-domain Transcription Factor Brn-3.1 in Hair Cell Development.- III. Genes and Deafness.- 9. Genetic Linkage Studies of Hereditary Hearing Loss.- 10. Mitochondrial Mutations and Hearing Loss.- 11. Loss and Regeneration of Cochlear Hair Cell Innervation following Sound and Drug Damage.- 12. Mechanism and Prevention of Aminoglycoside-Induced Hearing Loss.- 13. Neurotrophic Signaling by Membrane Electrical Activity in Spiral Ganglion Neurons.- 14. Protection of Cochlear Hair Cells from Gentamicin Ototoxicity and Mechanisms of Mammalian Hair Cell RegenerationIn Vitro.- 15. Protection and Regeneration of Vestibular Hair Cells—The Role of Neurotrophins after Gentamicin Ototoxicity.- IV. Gene-Based Therapy for Sensorineural Hearing Loss.- 16. Inner Ear Gene Therapy.- 17. Adeno-Associated Virus Mediated Gene Transfer in the Peripheral Auditory System.- 18.Herpes SimplexViral Vector Gene-Based Therapy to Prevent Loss of Auditory Sensory Cells from Stress-Induced Apoptosis.- Contributors list.

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