Overview

Cell adhesion plays a central role in development and disease. Cell adhesion to particular ligands can affect cytoskeletal organization and cell polarity, cell proliferation, and gene expression. This book is divided into two parts. The first section provides a discussion of the structure and function of the seven major classes of cell adhesion molecules: integrins, cadherins, selectins, heparan sulfate proteoglycans, the immunoglobulin superfamily, the ADAMs proteins, and transmembrane protein tyrosine phosphatases. The roles of these cell adhesion proteins in important processes such as cell mediated immunity, development and disease are discussed. In the second section, the molecular organization and function of junctional complexes, regions of the cell surface that are highly specialized for cell adhesion, are examined. Junctional complexes are now known to mediate adhesive interactions and contribute to transmembrane signaling events that dramatically influence cell behaviour.The biochemical organization of the adhesive membranes and the molecular mechanisms by which they transmit information to the cell are addressed.Written by contributors among the most prominent in the field, Cell Adhesion covers a wide range of topics in a single volume. It will be a great resource for students, teachers and researchers.

Full Product Details

Author:   Mary C Beckerle (Huntsman Cancer Institute and Department of Biology, University of Utah, USA)
Publisher:   Oxford University Press
Imprint:   Oxford University Press
Volume:   39
Dimensions:   Width: 18.80cm , Height: 2.40cm , Length: 24.50cm
Weight:   0.949kg
ISBN:  

9780199638710

ISBN 10:   0199638713
Pages:   426
Publication Date:   21 February 2002
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

1: Hansjurgen Volkmer: The immunoglobulin superfamily of cell adhesion molecules 2: Rodger P McEver: Selectins 3: Glenn L Radice and Masatoshi Takeichi: Cadherins 4: Bette Dzamba, Margaret Bolton and Douglas Desimone: The integrin family of cell adhesion molecules 5: Ofer Reizes, Pyong Woo Park, and Merton Bernfield: Cell surface heparan sulfate proteoglycans 6: Judith White, Dora Bigler, Michellee Chen, Yuji Takahashi, and Tyra Wofsberg: ADAMs 7: Susann Brady-Kalnay: Protein tyrosine phosphatases 8: Cara Gottardi, Carien Niessen, Barry Gumbiner: The adherens junction 9: Lynda Peterson and Keith Burridge: Focal adhesions and focal complexes 10: Leslie Bannon, Lawrence Goldfinger, Jonathan Jones, Kathleen Green: Desmosomes and hemidesmosomes 11: Shoichiro Tsukita, Mikio Furuse, Masahiko Itoh: The tight junction

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