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Author:   Binghe Wang (Georgia State University, Atlanta) ,  Leo E. Otterbein
Publisher:   John Wiley & Sons Inc
Imprint:   John Wiley & Sons Inc
Dimensions:   Width: 1.00cm , Height: 1.00cm , Length: 1.00cm
Weight:   0.454kg
ISBN:  

9781119783404

ISBN 10:   1119783402
Pages:   560
Publication Date:   24 May 2022
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

List of Contributors viii Preface: Carbon Monoxide: Promises and Challenges in Its Pharmaceutical Development xii Section I General Background and Physiological Actions 1 1 Endogenous CO Production in Sickness and in Health 3 Ladie Kimberly De La Cruz and Binghe Wang 2 Molecular Mechanisms of Actions for CO: An Overview 27 Rodrigo W. Alves de Souza, Leo E. Otterbein, and Nils Schallner 3 Pharmacokinetic Characteristics of Carbon Monoxide 44 Xiaoxiao Yang, Mingjia Wang, Chalet Tan, Wen Lu, and Binghe Wang 4 Carbon Monoxide and Energy Metabolism 88 Daniela Dias-Pedroso, Nuno Soares, and Helena L.A. Vieira 5 Role of CO in Circadian Clock 97 Hiroaki Kitagishi and Ikuko Sagami 6 Carbon Monoxide and Mitochondria 108 Claude A. Piantadosi 7 Carbon Monoxide, Oxygen, and Pseudohypoxia 118 Grace E. Otterbein, Michael S. Tift, and Ghee Rye Lee 8 Nitric Oxide in Human Physiology: Production, Regulation, and Interaction with Carbon Monoxide Signaling 136 Maryam K. Mohammed and Brian S. Zuckerbraun 9 When Carbon Monoxide Meets Hydrogen Sulfide 160 Rui Wang Copyrighted Material 10 Biliverdin and Bilirubin as Parallel Products of CO Formation: Not Just Bystanders 175 Libor Vitek Section II Delivery Forms 195 11 Delivery Systems and Noncarrier Formulations 197 James Byrne, Christoph Steiger, Jakob Wollborn, and Giovanni Traverso 12 Metal-Based Carbon Monoxide-Releasing Molecules (CO-RMs) as Pharmacologically Active Therapeutics 203 Roberta Foresti, Djamal Eddine Benrahla, Shruti Mohan, and Roberto Motterlini 13 Organic CO Donors that Rely on Photolysis for CO Release 223 Yi Liao 14 Organic Carbon Monoxide Prodrugs that Release CO Under Physiological Conditions 232 Zhengnan Yuan and Binghe Wang 15 Targeted Delivery of Carbon Monoxide 259 Lisa M. Berreau 16 Anesthesia-Related Carbon Monoxide Exposure 286 Richard J. Levy 17 Natural Products that Generate Carbon Monoxide: Chemistry and Nutritional Implications 302 Ladie Kimberly De La Cruz and Binghe Wang Section III Carbon Monoxide Sensing and Scavenging 319 18 Fluorescent Probes for Intracellular Carbon Monoxide Detection 321 Ryan R. Walvoord, Morgan R. Schneider, and Brian W. Michel Section IV Therapeutic Applications 345 19 CO in Solid Organ Transplantation 347 Roberta Foresti, Roberto Motterlini, and Stephan Immenschuh 20 Carbon Monoxide in Lung Injury and Disease 360 Stefan W. Ryter 21 Carbon Monoxide in Acute Brain Injury and Brain Protection 377 Alexandra Mazur, Madison Fangman, Rani Ashouri, Hannah Pamplin, Shruti Patel, and Sylvain Doré 22 CO as a Protective Mediator of Liver Injury: The Role of PERK in HO-1/ CO-Mediated Maintenance of Cellular Homeostasis in the Liver 385 Yeonsoo Joe, Jeongmin Park, Mihyang Do, Stefan W. Ryter, Young-Joon Surh, Uh-Hyun Kim, and Hun Taeg Chung 23 CO and Cancer 401 James N. Arnold and Joanne E. Anstee 24 CO and Diabetes 423 Rebecca P. Chow and Hongjun Wang 25 Carbon Monoxide and Acute Kidney Injury 434 Mark de Caestecker 26 CO as an Antiplatelet Agent: An Energy Metabolism Perspective 453 Patrycja Kaczara, Kamil Przyborowski, Roberto Motterlini, and Stefan Chlopicki 27 CO in Gastrointestinal Physiology and Protection 466 Katarzyna Magierowska and Marcin Magierowski 28 Carbon Monoxide and Sickle Cell Disease 482 Edward Gomperts, John Belcher, Howard Levy, and Greg Vercellotti 29 CO and Pain Management 497 Olga Pol 30 Clinical Trials of Low-Dose Carbon Monoxide 511 Edward Gomperts, Andrew Gomperts, and Howard Levy Index 528

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Author Information

Binghe Wang, PhD, is Regents’ Professor of Chemistry, Georgia Research Alliance Eminent Scholar, and Director for the Center for Diagnostics and Therapeutics at Georgia State University. Leo E. Otterbein, PhD, is Professor of Surgery at Harvard Medical School.

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