Overview

In this volume, glycochemistry and glycobiology have been combined to demonstrate the contribution of organic chemistry, modern analytics, biological and biochemical expertise to the increasingly important field of glycomics. A polysaccharide immunomodulator with therapeutic implications, carbohydrate vaccines, new findings emphasizing the influence of carbohydrate decoration on the regulation of inflammatory response and new therapeutic approaches in the treatment of acute and chronic inflammatory diseases, recent progress on glycoengineering based on a glycosylation strategy to optimize protein drugs, congenital disorders of glycosylation, and key aspects of the glycosylation changes associated with bladder cancer are amongst the subjects presented in this volume. The contribution of glycochemistry to innovation in glycosciences is shown with chapters covering highly functionalized exo-glycals for the generation of molecular diversity in a chemoselective manner, imino sugar glycosidase inhibitors, carbasugars, multivalent glycoconjugates, including glycodendrimers, glyconanotubes, and glyconanoparticles, and their uses in medicinal chemistry, as well as artificial saccharide-based and saccharide-functionalized gene delivery systems. Siderophores based on monosaccharides (which have proven effective for Gram-negative bacteria and mycobacteria), and the so-called smart materials, (which can modulate and control cell behaviour), complete the volume. Volume 39 of Carbohydrate Chemistry - Chemical and Biological Approaches contains contributions ranging from glycochemistry to glycobiology. This volume demonstrates in a meaningful way how the interdisciplinary approach of an international glyconetwork can advance the field of carbohydrate research in Europe and worldwide.

Full Product Details

Author:   Amélia Pilar Rauter (Universidade de Lisboa, Portugal) ,  Thisbe Lindhorst (Kiel University, Germany) ,  Somsak Laszlo ,  Jian Liu
Publisher:   Royal Society of Chemistry
Imprint:   Royal Society of Chemistry
Volume:   Volume 39
Dimensions:   Width: 15.60cm , Height: 2.20cm , Length: 23.40cm
Weight:   0.540kg
ISBN:  

9781849735872

ISBN 10:   1849735875
Pages:   258
Publication Date:   18 June 2013
Audience:   Professional and scholarly ,  Professional and scholarly ,  Professional & Vocational ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Synthetic Lipoarabinomannans as Inhibitors of Mycobaterial Growth; Epoxy carbohydrate derivatives and analogues as useful intermediates in the synthesis of glycosidase inhibitors; Recent design in the inhibition of glycosyltransferases; Beta-N-Acetylhexosaminidases: Group-specific inhibitors wanted...; Structure Determination of Lectins by X-ray Crystallography; Glycation: from molecules to life; Radical-mediated brominations at ring positions of carbohydrates - 35 years later; Glycosidases and diabetes type II: mode of action and therapeutic perspectives; Recent Advances in Enzymatic Synthesis of Heparin; Decoration of bacterial capsular polysaccharide. Their importance for vaccine development; Positive Attitude, Shape, Flexibility, Added-Value Accessoires or “Just Being Different”: How to Attract a Glycosidase; Surface Binding Sites in Carbohydrate Active Enzymes.

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Author Information

Amelia Pilar Rauter is Head of Carbohydrate Chemistry Group in the Chemistry and Biochemistry department of the University of Lisbon, Portugal. Thisbe K Lindhorst is Professor of Organic and Bioorganic Chemistry at the University of Kiel, Germany.

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