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Author:   Colin R. Martin (Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director: Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK) ,  Vinood B. Patel (Reader, University of Westminster, London, UK) ,  Victor R. Preedy (Emeritus Professor, King's College London; Professor, King's College Hospital, London, UK)
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
ISBN:  

9780443187599

ISBN 10:   0443187592
Pages:   570
Publication Date:   01 June 2023
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Forthcoming
Availability:   Not yet available  
This item is yet to be released. You can pre-order this item and we will dispatch it to you upon its release.

Table of Contents

Cannabis Use, Neurobiology, Psychology, and Treatment I. Setting the scene and introductory chapters 1. Metabolomics of the cannabis plant; 2. The roots of Cannabis sativa: chemical and pharmacological profile; 3. Cannabis related compounds in beverages and food; 4. The impact of prenatal cannabis exposure: an overview; 5. Cannabinoid Genotoxicity and Congenital Anomalies: A Convergent Synthesis of European and USA Datasets; 6. Cannabis Genotoxicity and Cancer Incidence: A Highly Concordant Synthesis of European and USA Datasets; 7. Cannabis, Cognitive impairment and Car Crash risk II. Cannabis usage 8. Recreational cannabis use: a French perspective of adverse effects; 9. Acute and chronic impact of cannabis on human cognition; 10. Polydrug users, use of cannabidiol (CBD) and abuse potential/Polydrug users, use of cannabinoids and abuse potential; 11. Cannabis stigmas: a narrative of features; 12. Alterations of THC and CBD ratios and impact on cognition; 13. When cannabis is used for medicinal purposes: a focus on back pain III. Pharmacological and Physiological Aspects 14. Cannabis, cannabinoids and receptor responses; 15. Cannabidiol (CBD): abuse potential and withdrawal; 16. 4,5- Dihydro-1H-pyrazole/3,4-Diarylpyrazoline class of cannabinoid-1 (CB1R) receptor antagonists and their potential in medicinal applications IV. Neurobiology of cannabis 17. Neurobiology of cannabis; 18. The kynurenine pathway, neurobiology and cannabis misuse: a new narrative; 19. Central nervous system cancers and use of cannabis and related products: an updated narrative; 20. Chronic cannabis users: links with glutamate and resting state connectivity; 21. Brain metabolic responses to cannabis use in people with multiple sclerosis: Insights from [18F]-FDG positron emission tomography and functional MRI; 22. Genetic Variation and Acute Responses to Cannabis; 23. Cell Signaling of the CB1 Cannabinoid Receptor via beta-arrestins, Cannabinoid Receptor Interacting Protein (CRIP1a) and other regulatory proteins; 24. Cannabis and impact on memory: from in utero to adults; 25. Central CB1 receptors and age-related changes: investigating the effects of DELTA-9-tetrahydrocannabinol; 26. Alcohol, cannabis and visual memory V. Neurobiology of cannabinoids 27. The role of Delta-FosB in the plasticity of the cannabinoid system; 28. Functional profile of synthetic cannabinoid receptor agonists: exploring cannabinoid and non-cannabinoid targets; 29. Linking the G protein-coupled orphan receptor GPR55 to the cannabinoid receptors (CB1 and CB2): a new narrative; 30. Proteomic analysis of cannabinoids in human oligodendrocytes; 31. Cannabinoids and endocannabinoid signaling at the basal forebrain cholinergic system; 32. Cannabidiol (The major non-psychotropic cannabinoid in the cannabis plant) and the PI3K/Akt pathway in the CNS; 33. Effects of cannabidiol and other phytocannabinoids on ion channels;34. Cannabis, neurodevelopment and the two-hit hypothesis VI. New and synthetic cannabinoids 35. Impact of tetrahydrocannabinol (THC ) and synthetic spice cannabinoids on nicotine use and abuse; 36. Synthetic cannabinoids: how do they compare to DELTA9-tetrahydrocannabinol: neurological effects and beyond VII. Biomarkers, analysis and screening 37. The DSM-5 criteria of cannabis use disorder: methods and applications; 38. Cannabis and clinical high risk for psychosis: monitoring and smartphones VIII. Impact on non-neurological systems 39. The impact of cannabis and cannabinoids on the skin; 40. Cannabis consumption in reproduction and teratogenicity; 41. Cannabis compounds and putative cytotoxicity: profile of cancer cells IX. Treatments, strategies and resources 42. Motivational Interviewing for Cannabis Use Disorders: a narrative review from research to practice; 43. An Overview of Current Pharmacologic Interventions for Management of Cannabis Withdrawal and the Evidence for Their Use; 44. Managing cannabinoid hyperemesis syndrome in paediatrics: A new narrative review; 45. Gabapentinoids for the Treatment of Cannabis Use Disorder: A Focus on Human Laboratory Research; 46. Treating psychosis in users of synthetic cannabinoids X. Resources 47. Cannabis and Web based Resources Medicinal Usage of Cannabis and Cannabinoids I. Setting the scene and introductory chapters 1. How medical cannabis may influence the future of medicine; 2. Medical cannabis and cannabinoids: how best to extract components from plant material; 3. Medicinal usage of cannabis and its impact on mental health among cancer patients and survivors; 4. Cannabis sativa as a traditional phytomedicine: a new narrative covering different countries; 5. Medical use of cannabis in the middle east; 6. What medicinal cannabis is used for: a focus on Canada; 7. New York perspectives of medical cannabis laboratory analysis; 8. Epigenetic regulations on the quality of clonal cannabis plants: secondary metabolites and profiles; 9. Aberrant use of medicinal cannabis: theoretical and empirical considerations; 10. Profile of older users of medical cannabis and cannabinoids; 11. Use of cannabidiol oil by caregivers: a focus on Alzheimer's disease; 12. Medicinal use of cannabis: adverse events as a balanced perspective II. Physiological aspects and metabolic aspects 13. Physiopathology and use of cannabinoids for fibrotic diseases; 14. Cannabinoids in inflammation and atherosclerosis; 15. Targeting the CB(2) receptors and other endocannabinoid elements to delay disease progression in cardiovascular diseases; 16. BMI in cannabis users: regulation, mechanisms and public health impact III. Neurological, psychological and behavioural aspects 17. Neuroprotection by cannabis related products, cannabidiol and cannabigerol, and associated mechanisms of action; 18. Cannabis terpenes as neuroprotective agents: a focus on alpha-bisabolol; 19. Cannabidiol in medicinal usage of stress: modelling investigations into cocaine; 20. Medicinal cannabis and neurocognition impairment; 21. Genetic models of audiogenic seizures: what they are and how cannabinoids and Cannabis-derived compounds can be used to alleviate their symptoms - an updated narrative; 22. Addressing the validity of cannabinoid therapy as an option for the treatment of substance use disorder IV. Pharmacological and cellular aspects 23. Cannabidiolic acid (CBDA), features and profiles: anti-hyperalgesic effects; 24. Cannabis-drug interactions: implications for medicinal cannabis use; 25. Cannabinoid receptor subtype 2 (CB2R): features and targets for medical applications; 26. Medical use of cannabidiol and impact on cancer cell viability; 27. Anti-inflammatory and antioxidant and immunomodulatory effects of phytocannabinoid -caryophyllene: A mechanistic overview V. Symptom Control and Medicinal Uses 28. Cancer patients and providers: Attitudes and beliefs of cannabis and cannabinoids use as a treatment; 29. CBD (cannabidiol) use in breast cancer chemotherapy; 30. Sleep: cannabis and cannabinoids use; 31. Cannabis and cannabis related products and their uses in aiding sexual health of men and women; 32. Symptom control in palliative care settings: The role of cannabis-based medicines; 33. Cannabidiol (CBD) Use in Fragile X Spectrum Disorders; 34. Hempseed (Cannabis sativa) and ameliorative effects in hypercholesterolemia; 35. Benzodiazepines and cannabis use; 36. Features of (+)-trans-cannabidiol-2-hydroxy pentyland applications to disease: a focus on usage in diabetic nephropathy; 37. Medical use of cannabis: applications to Tourette syndrome; 38. Cannabinoids and their use in chronic non-cancer pain: a new narrative review; 39. Endometriosis: features and potential role of medical cannabis; 40. Cannabis usage for Crohn's disease and ulcerative colitis: a narrative; 41. Medical cannabis and use in migraine; 42. Cannabidiol (CBD ) and potential in medicinal use in rheumatoid arthritis; 43. Role of Cannabinoids in Glaucoma: Lowering Intraocular Pressure or Neuroprotection; 44. Medicinal potential of anandamide as a representative endocannabinoid and its effect at the cellular level in skin VI. Resources 45. Medical Cannabis and Resources Neurobiology, Physiology, And The Endocannabinoid System I. Setting the scene and introductory chapters 1. Distribution of the endocannabinoid system: linking signalling and development; 2. The endocannabinoid system, immunomodulation, and LPS-induced inflammation; 3. Physiology of the endocannabinoid systems: imaging and the use of positron emission tomography (PET); 4. The endocannabinoid system and aging; 5. The endocannabinoid system and post traumatic stress disorder (PTSD): a new narrative II. Neurobiology of the endocannabinoid system 6. The protective effect of the endocannabinoid system in neurotoxin induced damage to hippocampal neurons: a focus on light and electron microscopy; 7. Endocannabinoid Signaling and excitatory and inhibitory synapses; 8. The endocannabinoids and potassium channels: an updated narrative; 9. Social interactions and neural activity: linking cellular studies and endocannabinoid signalling; 10. Exercise and Parkinson's disease: linking in the cannabinoid type 1 (CB1) and type 2 (CB2), and mu-opioid receptors; 11. The endocannabinoids system and endocannabinoid receptors in sleep; 12. Endocannabinoids and inhalant misuse: neuropsychological aspects; 13. Fatty acid amide hydrolase (FAAH) in substance use disorders: FAAH regulation and inhibition in cannabis, alcohol, nicotine, stimulant, and opioid use disorders; 14. Treatment of pain with dual fatty acid amide hydrolase (FAAH) enzyme and human soluble epoxide hydrolase (sEH) enzyme inhibitors: interlinking the endocannabinoid system; 15. WWL70: linking the hydrolyses 2-arachidonoylglycerol, endocannabinoid and eicosanoid pathways: therapeutic potential and neurological disease; 16. Endocannabinoid catabolic enzyme inhibitors and pain alleviation; 17. The endocannabinoid system in health and disease: features in epilepsy; 18. The endocannabinoid system and autoimmune demyelination: a focus on multiple sclerosis; 19. Endocannabinoid signaling and the lateral habenula; 20. On the interplay among endocannabinoid, noradrenergic and glucocorticoid systems: evidence from aversive memory studies III. Receptor biology and responses 21. Adenosine A2A-cannabinoid CB1 receptor heteromers in the brain: From trans-inhibition to trans-activation; 22. Hippocampal CB1, CB2 receptors, the endocannabinoid system and fear memory; 23. Beta-caryophyllene, the CB2 cannabinoid receptor-specific agonists and wound healing; 24. The nigrostriatal dopaminergic pathway: impact of WIN 55212-2 as a potent cannaboinoid receptor agonist; 25. Peripheral cannabinoid receptor 1 antagonists and impact on adipocytes; 26. Endocannabinoid system receptors in plasma membranes : extraction, lipid rafts and the cortex; 27. Applications to wound healing: cannabinoid receptor 1 antagonism and collagen deposition; 28. Role of the Transient Receptor Potential Vanilloid 1 (TRPV1), a component of the endocannabinoid system, in anxiety, depression, and cocaine addiction; 29. Allosteric modulators of the endocannabinoid system: Org27569 and cannabinoid receptor 1 (CB1); 30. Naturally occurring DELTA-9-tetrahydrocannabinol-derivatives and binding to CB1 and CB2 receptors: Linking in the endocannabinoid system IV. Profiles and behaviour of selective endocannabinoids 31. New cannabinoid receptor type 1 and 2 agonists and applications to understanding the endocannabinoid system; 32. Fatty acid amide hydrolase, the endocannabinoid anandamide and neurological disease; 33. The endocannabinoid-system in the immuno-biology of dendritic cells; 34. Palmitoylethanolamide and other anandamide congeners in neuroinflammation-based disorders: linking in the endocannabinoid system; 35. Endocannabinoid modulation of synaptic function and behavior in the dorsomedial hypothalamus; 36. Key role of anandamide and the endocannabinoid system in the modulation of cardio-renal homeostasis; 37. The endocannabinoid system: Signaling and social motivation V. Exogenous, synthetic other compounds linking in the endocannabinoid system 38. Safety and toxicology of the dietary cannabinoid beta-caryophyllene; 39. Synthetic cannabimimetics: an overview VI. Compartive studies in non neurological systems 40. Non Neurological Aspects of the Endocannabinoid System: Non Alcoholic Fatty Liver Disease; 41. Components of the Endocannabinoid system: Hepatic expression levels of the cannabinoid receptors and microRNAs; 42. Tumour growth and the endocannabinoid system: investigating CB2 agonists; 43. Linking Endocannabinoid System, Palmitoylethanolamide and Sarcopenia in view of therapeutic outcomes VII. Resources 44. Endocannabinoids and Resources

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Author Information

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017). Dr. Patel is a Reader at the University of Westminster. After completing his PhD at King's College London, he continued his research experience by undertaking his post-doctoral studies in the laboratory of Professor Cunningham in the Department of Biochemistry at the Wake Forest University School of Medicine, (Winston-Salem, NC, USA). This extensive project involved investigating mechanisms of hepatic mitochondrial ribosome dysfunction in alcoholic liver disease (ALD) using biophysical and proteomic techniques. These studies have led to new avenues in determining the pathology of ALD. His teaching areas at both post-graduate and undergraduate levels include clinical biochemistry, investigative pathology and laboratory investigation. Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is Emeritus Professor of Nutritional Biochemistry, at King's College London and Professor of Clinical Biochemistry (Hon) at King's College Hospital. He was the long-term Director of the Genomics Centre at King's College London from 2006 to 2020. Professor Preedy has carried out research when attached to Imperial College London, The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with research groups in Finland, Japan, Australia, USA and Germany. Prof. Preedy is a leading expert on the science of health and has a long-standing interest in dietary and plant-based components. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

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