Overview

Developmental cancer products (oncodevelopmental markers, ODM) not only serve as diagnostic and prognostic indicators but also may be used to study the nature of the carcinogenic process and the biology of tumors. For many years oncologists have searched for markers of cancer cells that would permit unequivocal recognition of cancer in contrast to noncancerous tissue. The earliest and still most widely used method of identification of cancer tissue or cells is the structural resemblance of cancer tissue to fetal or immature tissue. Pathologists not only recognize cancer by its morphologic similarity to fetal tissues, but also in many instances can relate the behavior of a given tumor to the degree of tissue differentiation. Thus, poorly differentiated tumors that resemble fetal tissue generally grow more rapidly and metastasize earlier than do well-differentiated tumors that more closely resemble adult tissue. In recent years the commonality of fetal and cancer tissue has been extended to products of tumor cells that, can be analyzed by biochemical, immunological, or physiological techniques. Increas­ ingly, products of cancer cells similar to fetal products are being identified and studied. These products range from cell-surface markers (fetal or differentiation antigens), placental proteins, hormones, and isoenzymes to a multitude of products, such as carcinoembryonic antigen (CEA), alphafetoprotein (AFP), lymphocyte markers, and nucleic acids, such as tRNA, that are produced in small amounts by v vi PREFACE continually differentiating cells in the adult but in much greater amounts by tumors.

Full Product Details

Author:   Stewart Sell
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   Softcover reprint of the original 1st ed. 1980
Volume:   1
Dimensions:   Width: 15.50cm , Height: 2.90cm , Length: 23.50cm
Weight:   0.866kg
ISBN:  

9781461261193

ISBN 10:   1461261198
Pages:   541
Publication Date:   12 October 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1 Teratocarcinoma.- 2 Mouse Lymphocyte Differentiation Markers.- 3 Monoclonal Immunoglobulins As Biomarkers of Cancer.- 4 Markers in Human Lymphoid Tumors.- 5 Oncofetal Transplantation Antigens.- 6 Antigens and the Major Histocompatibility Complex.- 7 Hormone-Secreting Tumors.- 8 Enzymes and Isoenzymes in Cancer.- 9 Pregnancy Proteins as Tumor Markers.- 10 Alphafetoprotein.- 11 Carcinoembryonic Antigen A: Chemistry and Biology.- 12 Theoretical and Practical Consideration of the Utility of the Radioimmunoassay for Carcinoembryonic Antigen (CEA) in Clinical Medicine.- 13 Antigens Associated with Human Solid Tumors.- 14 Surface Glycolipid and Glycoprotein Antigens.- 15 Lectin Interactions with Normal and Tumor Cells and the Affinity Purification of Tumor Cell Glycoproteins.- 16 Transfer RNA and Its By-Products as Tumor Markers.- 17 Nonhistone Protein Antigens.- 18 Fibronectin.- 19 Circulating Immune Complexes in Cancer.

Reviews

. ..a highly useful, concise encyclopedia providing introduction to stem cells as well as special topics in the state-of-the-art stem cell research. - Pharmaceutical Research

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