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Author:   Graham Dellaire ,  Jason N. Berman ,  Robert J. Arceci
Publisher:   Elsevier Science Publishing Co Inc
Imprint:   Academic Press Inc
Dimensions:   Width: 21.60cm , Height: 3.00cm , Length: 27.60cm
Weight:   1.610kg
ISBN:  

9780123969675

ISBN 10:   0123969670
Pages:   510
Publication Date:   12 December 2013
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

Introduction 1. Historical Overview Methodological Approaches and Background 2. Expression Arrays (SNPs, etc.) 3. Tissue micro-arrays (breast, ovarian) 4. Next generation sequencing (DNAseq) 5. RNAseq (breast cancer, sarcomas) 6. Epigenetic Analyses 7. Pharmcogenomics 8. Biomarker discovery through genomics 9. Preclinical models for genomics (cell culture, transgenic animals, xenografts) 10. Bioinformatics and computational methods for data analysis 11. Genomic Resource Projects - The Cancer Genome Atlas (TCGA) International Cancer Genome Consortium (ICGC) Ethics of Genomics Research 12. Ethics of Genomics Research The Genomics, Epigenomics and Transcriptomics of Cancer 13. Somatic mutations, Transcription and Epigenetics Overview Adult Solid Tumors 14. Lung Cancer 15. Breast Cancer 16. Prostate Cancer 17. Colon Cancer 18. Thyroid Cancer Age Non-specific Tumors and Hematopoietic Malignancies 19. ALL 20. AML 21. NHL 22. Multiple Myeloma 23. Brain Tumors Pediatric Cancers 24. Neuroblastoma 25. Soft tissue sarcomas 26. Osteosarcoma 27. Wilms Tumors Germline Mutations and Hereditary Cancer Syndromes 28. Germline Mutations and Hereditary Cancer Syndromes Future Directions 29. The role of microRNAs and ultraconserved non-coding RNAs in cancer 30. Environmental impact on cancer genomics

Reviews

.provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. --Anticancer Research 34, 2014

...provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. --Anticancer Research 34, 2014

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