Cancer and Zebrafish: Mechanisms, Techniques, and Models

Author:   David M. Langenau
Publisher:   Springer International Publishing AG
Edition:   Softcover reprint of the original 1st ed. 2016
Volume:   916
ISBN:  

9783319808604


Pages:   552
Publication Date:   27 May 2018
Format:   Paperback
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Our Price $448.77 Quantity:  
Add to Cart

Share |

Cancer and Zebrafish: Mechanisms, Techniques, and Models


Add your own review!

Overview

This volume focuses on defining the unique attributes of using the zebrafish cancer model for discovering important pathways and potential drug targets for the treatment of human cancers. Using the zebrafish model, the volume explores oncogene and tumor suppressor discovery, chemical genetic approaches, genomics, epigenetics, cancer imaging, and cell transplantation. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish cancer models, including T cell leukemia, rhabdomyosarcoma, liver and pancreatic cancer, melanoma, neuroblastoma, germ cell tumors, and malignant peripheral sheath tumors. A chapter is also dedicated to the development and utilization of other piscine models of cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and cancer, providing a much needed resource on the powerful attributes of the zebrafish model system.

Full Product Details

Author:   David M. Langenau
Publisher:   Springer International Publishing AG
Imprint:   Springer International Publishing AG
Edition:   Softcover reprint of the original 1st ed. 2016
Volume:   916
Dimensions:   Width: 15.50cm , Height: 2.90cm , Length: 23.50cm
Weight:   8.424kg
ISBN:  

9783319808604


ISBN 10:   3319808605
Pages:   552
Publication Date:   27 May 2018
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand   Availability explained
We will order this item for you from a manufactured on demand supplier.

Table of Contents

​Part 1. Powers Of The Zebrafish Model.- 1. Uncharted Waters: Zebrafish Cancer Models Navigate A Course for Oncogene Discovery.- 2. The Toolbox for Conditional Zebrafish Cancer Models.- 3. Approaches to Inactivate Genes in Zebrafish.- 4. Tumor Suppressors in Zebrafish: From Tp53 To Pten and Beyond.- 5. Identifying Novel Cancer Therapies Using Chemical Genetics and Zebrafish.- 6. Genomic Approaches To Zebrafish Cancer.- 7. Transcriptomic Analyses in Zebrafish Cancer Models for Global Gene Expression and Pathway Discovery.- 8. Zebrafish Discoveries in Cancer Epigenetics.- 9. Lymphatics, Cancer and Zebrafish.- 10. In Vivo Imaging of Cancer in Zebrafish.- 11. Imaging Cancer Angiogenesis and Metastasis in A Zebrafish Embryo Model.- 12. Allograft Cancer Cell Transplantation in Zebrafish.- 13. The Zebrafish Xenograft Platform: Evolution of A Novel Cancer Model and Preclinical Screening Tool.- 14. Automation of Technology for Cancer Research.- Part 2. Cancer Models in Fish.- 15. Zebrafish Models Of Human Leukemia: Technological Advances and Mechanistic Insights.- 16. Zebrafish Rhabdomyosarcoma.- 17. Baiting for Cancer: Using The Zebrafish as A Model in Liver And Pancreatic Cancer.- 18. How Zebrafish Are Helping Us To Target Colorectal Cancer.- 19. Zebrafish Melanoma.- 20. Neuroblastoma and Its Zebrafish Model.- 21. Zebrafish Germ Cell Tumors.- 22. Malignant Peripheral Nerve Sheath Tumors.- 23. Xiphophorus and Medaka Cancer Models.

Reviews

Author Information

Dr. Langenau is an Associate Professor at Harvard Medical School and Associate Pathologist at the Massachusetts General Hospital.  Dr. Langenau is joint-appointed through the Department of Pathology, the Cancer Center and the Center for Regenerative Medicine at the Massachusetts General Hospital. Dr. Langenau is also a principal faculty member at the Harvard Stem Cell Institute (HSCI) and a member of the Dana-Farber/Harvard Cancer Center. Dr. Langenau runs an active research group that focuses on uncovering mechanisms of progression and relapse in pediatic cancer.  He has become a pioneer in using zebrafish to understand human cancer biology. His group has used the zebrafish model to dynamically visualize the hallmarks of cancer in live animals, to develop drug screening approaches to kill relapse-driving tumor propagating cells, and to uncover oncogenic drivers conserved in zebrafish and humans using bioinformatic approaches and cross-species comparisons.

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions
Latest Reading Guide

RGJUNE2025

 

Shopping Cart
Your cart is empty
Shopping cart
Mailing List