Overview

The quest to discover the aetiology of schizophrenia has fascinated and frustrated researchers for more than a century. In recent years, there has been an accumulation of experimental and epidemiological evidence supporting the role of viral infections in schizophrenia pathogenesis. This growing body of evidence has amassed to the point where the mainstream scientific community can no longer ignore it. Drawing on his research experience in biological psychiatry and neurovirology, Dr. Pearce provides a book dedicated entirely to a critical appraisal of the viral hypothesis of schizophrenia. This book should be an enlightening and valuable resource for psychiatrists, psychologists, neurobiologists, and their students. By integrating findings in virology and immunology with concepts in the pathophysiology of the non- affective psychotic disorders, this volume disentangles the various sub-theories of the viral hypothesis, and lays the groundwork for more focused explorations of the mechanisms by which viruses may cause serious mental illness.

Full Product Details

Author:   Bradley D. Pearce
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2003 ed.
Volume:   6
Dimensions:   Width: 15.50cm , Height: 1.10cm , Length: 23.50cm
Weight:   0.910kg
ISBN:  

9781402073007

ISBN 10:   1402073003
Pages:   144
Publication Date:   30 November 2002
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

1 Introduction and History.- 1.1 A brief history of the viral hypothesis.- 2 Fundamentals of Viral Infections and Immune Responses in Humans.- 2.1 A primer on general virology.- 2.2 Immune response to viral infections.- 2.3 Persistent viral infections.- 3 Encephalitis and Schizophrenia.- 3.1 Viruses and schizophrenia: a plurality of theories.- 3.2 Psychosis in viral encephalitis.- 3.3 The validity gap for the encephalitis connection.- 3.4 Bona diseases virus.- 3.5 Viruses in other psychiatric diseases.- 4 Epidemiological Evidence.- 4.1 Epidemiological studies of the viral hypothesis.- 4.2 Seroepidemiological studies.- 4.3 Immune alterations in schizophrenia.- 5 The Role of Viral Infections During Neurodevelopment.- 5.1 Brain development.- 5.2 Immunology of the maternal-fetal unit.- 5.3 The viral-developmental hypothesis.- 5.4 Epidemiological studies of perinatal infections in adult schizophrenia.- 6 Model and Mechanisms.- 6.1 Specific models.- 6.2 A history lesson from oncology concerning the viral hypothesis.- 6.3 What a viral etiology of schizophrenia does not mean.- 6.4 Conclusion.

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