Overview

The text provides an up to the minute summary of what is known today about the biochemistry and pharmacology of the camptothecins. The chapter that covers this subject includes a discussion of the mechanism of action of topoisomerase I, and a review of the means by which camptothecins poison this enzyme. The use of animal models in defining the anticancer potential of camptothecins and a discussion of camptothecin resistance is included. Part two of the text is devoted to a review of new analogue development as well as drug delivery issues that are aimed at optimizing the anticancer activities of camptothecins. In the last section of the book the clinical perspective is presented. The authors have included current summaries on each of the members of the camptothecin families that have been studied in the clinic. Along with these reviews discussions of the potential use of camptothecins in a variety of different cancers has been included.

Full Product Details

Author:   Val R. Adams ,  Val R. Adams
Publisher:   Humana Press Inc.
Imprint:   Humana Press Inc.
Edition:   2005 ed.
Dimensions:   Width: 15.50cm , Height: 3.10cm , Length: 23.50cm
Weight:   0.962kg
ISBN:  

9781588290274

ISBN 10:   1588290271
Pages:   460
Publication Date:   01 February 2005
Audience:   College/higher education ,  Professional and scholarly ,  Undergraduate ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of stock  
The supplier is temporarily out of stock of this item. It will be ordered for you on backorder and shipped when it becomes available.

Table of Contents

Biochemistry, Pharmacology, and Chemistry.- Mechanism of Action of Topoisomerase 1 Poisons.- Crystallographic Insight Into the Mechanism of Drug-Induced Topoisomerase I DNA Damage.- Inhibitors of Topoisomerase I Function.- Cytotoxic Mechanisms of Topoisomerase 1 Inhibitors.- Biochemical and Genetic Analyses of DNA Topoisomerase 1-Mediated DNA Damage.- Preclinical Models for Evaluating Topoisomerase I-Targeted Drugs.- Mechanisms of Resistance to Camptothecins.- Recent Advances in Camptothecin Drug Design and Delivery Strategies.- Clinical Perspectives.- Clinical Experience With 9-Aminocamptothecin.- Clinical Studies of Rubitecan (9-Nitro 20(S) Camptothecin).- Irinotecan.- Clinical Experience With Topotecan.- The Clinical Development of Lurtotecan.- Preclinical and Clinical Development of Exatecan (DX-951f).- Camptothecins in the Treatment of Primary Brain Tumors.- Camptothecins in the Treatment of Lung Cancer.- Use of Camptothecins in the Treatment of Leukemia and Related Disorders.

Reviews

...an excellent all-around reference appropriate for researchers or clinicians in anticancer drug literature. - Doody's Health Science Book Review Journal

.,. an excellent all-around reference appropriate for researchers or clinicians in anticancer drug literature. - Doody's Health Science Book Review Journal

Author Information

Tab Content 6

Author Website:  

Customer Reviews

Recent Reviews

No review item found!

Add your own review!

Countries Available

All regions