Overview
Written by expert contributors, this much-needed book emphasizes a quantitative and comprehensive perspective to explore the many dimensions of cellular Ca2+ signalling. Leading researchers in the field of calcium signaling present key aspects of this process in cells, starting with Ca2+ entry into the cell, its uptake from the cytosol by organelles, such as the endoplasmic reticulum and mitochondria, and the actions of Ca2+ in turn on a variety of important cellular regulatory processes. This research and reference text should prove useful to a wide readership, from students to researchers at many different levels, particularly in physiology, pharmacology, or biomedical engineering. Key Features: Places a strong emphasis on Quantitative Biophysics Acts as a unique resource for state-or-the-art methods to study Ca2+ signals Includes emerging perspectives that link mechanistic insights to pathophysiological aspects of Ca2+ signalling Discusses a historical perspective on the development of key ideas in the field
Full Product Details
Author: Leslie S. Satin (University of Michigan Medical School) ,
Manu Ben-Johny (Columbia University) ,
Ivy E Dick (University of Maryland)
Publisher: Institute of Physics Publishing
Imprint: Institute of Physics Publishing
Weight: 0.030kg
ISBN: 9780750320078
ISBN 10: 0750320079
Pages: 398
Publication Date: 03 March 2023
Audience:
Professional and scholarly
,
Professional and scholarly
,
Professional & Vocational
,
Professional & Vocational
Format: Hardback
Publisher's Status: Active
Availability: In Print
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Author Information
Dr Leslie S. Satin is the Joanne I. Moore Endowed Research Professor of Pharmacology of the University of Michigan Medical School. He obtained his PhD from UCLA in the laboratory of D. Junge and conducted postdoctoral work at Stony Brook University with P. R. Adams and at the University of Washington, Seattle, with D. Cook. His research has focused on calcium signaling, ion channels, oscillations, and stimulus-secretion coupling in pancreatic beta cells. Manu Ben-Johny is an Assistant Professor in the Department of Physiology and Cellular Biophysics at Columbia University. He received a BS in Biomedical Engineering and Mathematics from Saint Louis University, and subsequently completed his PhD in Biomedical Engineering at Johns Hopkins University under the tutelage of David Yue. His lab focuses on the biophysics and physiology of voltage-gated sodium and calcium ion channels that shape cardiac and neuronal action potentials and in developing nature-inspired approaches to manipulate ion channel function. Ivy Dick is an assistant professor in the Physiology Department at the University of Maryland, School of Medicine. She began her career under the direction of Drs. Charles Cohen and Owen McManus at Merck Research Labs and subsequently earned her doctoral degree under the direction of Dr. David Yue in the Biomedical Engineering department at Johns Hopkins University, where she studied the mechanisms underlying calmodulin regulation of voltage-gated calcium channels. Dr. Dick’s current research focuses on understanding the mechanisms of voltage-gated calcium channel regulation, and how genetic mutations disrupt channel function.
