Overview

Recent years have witnessed an explosion of knowledge lea- ding to a molecular understanding of the mechanisms of ac- tion of calcium on excitation and contraction coupling and its role in the regulation of contractility. This book highlights the most recent progress as well as providing a historial perspective of the field. It presents a concise and comprehensive overview of our current knowledge regar- ding calcium channels and regulatory proteins as well as in- tracellular calcium handling and the mechanisms underlying the activation of contractile proteins. It also describes how these basic mechanisms have been adapted in various types of muscle, especially in cardiac and smooth muscle.

Full Product Details

Author:   Johann C. Rüegg
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2nd ed. 1992. Softcover reprint of the original 2nd ed. 1992
Dimensions:   Width: 17.00cm , Height: 2.00cm , Length: 24.20cm
Weight:   0.643kg
ISBN:  

9783642775628

ISBN 10:   3642775624
Pages:   354
Publication Date:   08 December 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. Muscle Excitation and Contraction.- 1.1 Muscle Excitation.- 1.2 Electromechanical Coupling.- 1.3 The Contractile Process.- 2. The Sarcoplasmic Reticulum: Storage and Release of Calcium.- 2.1 Inward Spread of Excitation in the Transverse System (T-System).- 2.2 Calcium Release from the Sarcoplasmic Reticulum (SR).- 2.3 Calcium Reuptake by the Sarcoplasmic Reticulum.- 3. The Dependence of Muscle Contraction and Relaxation on the Intracellular Concentration of Free Calcium Ions.- 3.1 Crustacean Muscle.- 3.2 Vertebrate Skeletal Muscle.- 4. Calcium Binding and Regulatory Proteins.- 4.1 Structure and Function of Troponin.- 4.2 Alterations of Thin Filaments Trigger Contraction.- 4.3 Ancillary Calcium-Binding Proteins: Calmodulin, Parvalbumin, and Myosin Light Chains.- 5. Diversity of Fast and Slow Striated Muscle.- 5.1 Vertebrate Tonic Muscle Fibres.- 5.2 Comparison of Mammalian Fast- and Slow-Twitch Fibres.- 5.3 Diversity of Crustacean Muscles.- 5.4 Insect Flight Muscle.- 5.5 Obliquely Striated Muscle of Annelids and Nematodes.- 5.6 Generalizations and Conclusions.- 6. Myosin-Linked Regulation of Molluscan Muscle.- 6.1 Calcium Regulation in the Striated Adductor of the Scallop.- 6.2 Catch Muscles.- 6.3 Summary.- 7. The Vertebrate Heart: Modulation of Calcium Control.- 7.1 Calcium-Transport Mechanisms.- 7.2 Calcium Movements as the Link Between Excitation and Contraction.- 7.3 Myoplasmic Free Calcium, a Major Determinant of Contractility.- 7.4 Alteration of Contractility by Changes in Calcium Responsiveness of Myofilaments.- 8. Vertebrate Smooth Muscle.- 8.1 Contractile Mechanism.- 8.2 Calcium Activation of the Contractile Apparatus.- 8.3 Regulation of the Intracellular Calcium Ion Concentration.- 8.4 Modulation of Calcium Activation by Cyclic Nucleotides and G-Proteins.- 9. Principles of Calcium Signalling in Muscle.- 9.1 Senders of Calcium Signals.- 9.2 Transmission of Calcium Signals.- 9.3 Diversity of Calcium-Signal Receivers.- 9.4 Contractile Responsiveness to Calcium.- 9.5 Feedback Signals and Servoloops.- 10. Molecular Level Approaches to Excitation-Contraction Coupling in Heart and Skeletal Muscle.- 10.1 Calcium Channels in T-System SR Coupling and Calcium Release.- 10.2 Control of the Contractile Mechanism by Intracellular Free Calcium.- 10.3 Concluding Remarks and Future Prospects.- References.

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