Overview

Since the publication of my previous monograph in 1974, important progress has been made in the broad area of calcium research, partic­ ularly as it pertains to secretory phenomena. The significant advance in methodology, while widening the scope of our knowledge, has caused research in this particular area to become more and more specialized. It has, therefore, become increasingly difficult for researchers to consider and evaluate work outside their own areas of specialization and to com­ prehend the field from a broad perspective. While many valuable re­ views on the importance of calcium in cellular function are being pro­ duced, they have not attempted to pull together all of the existing knowledge into a more general narrative. This volume brings together experimental data and theories from diverse sources, and attempts to synthesize into a broad conceptual framework the massive amount of specialized information that presently exists in the general area of cal­ cium metabolism and the secretory process. It is impossible in a book of this length to discuss specific references in detail and still maintain readability, so generalizations must be made.

Full Product Details

Author:   Ronald P. Rubin
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   Softcover reprint of the original 1st ed. 1982
Dimensions:   Width: 15.50cm , Height: 1.50cm , Length: 23.50cm
Weight:   0.450kg
ISBN:  

9781468442199

ISBN 10:   1468442198
Pages:   288
Publication Date:   17 March 2012
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
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Table of Contents

1 General Introduction.- A. Biological Importance of Calcium.- B. Methods for Analysis and Tissue Concentrations of Calcium.- C. Redistribution of Calcium during Stimulation.- D. Regulation of Cell Calcium.- E. Calcium and the Regulation of Membrane Permeability.- F. Calcium Ionophores.- G. Calcium Antagonists.- H. Summary and Conclusions.- 2 Survey of Calcium Action in Stimulus-Secretion Coupling.- A. General Features of the Secretory Process.- B. Historical Development of the Concept of Stimulus-Secretion Coupling.- C. Other Neuronal Systems.- D. Histamine Release from Mast Cells.- E. Lysosomal Enzyme Release from Neutrophils.- F. Blood Platelet Release Reaction.- G. Exocrine Secretion.- H. Gastric Secretion.- I. Endocrine Secretion.- J. Perspective.- 3 Nature of the Role of Calcium in Secretion.- A. Membrane Fusion.- B. Energy Metabolism and Secretion.- C. Microtubule, Microfilament System.- D. Secretion as a Contractile Event.- E. Calcium-Binding Proteins.- F. Phospholipid Metabolism.- 4 Interaction of Calcium with Other Putative Mediators.- A. Analysis of the Role of Cyclic AMP in Secretion.- B. Analysis of the Role of Cyclic GMP in Secretion.- C. Analysis of the Role of Prostaglandins in Secretion.- Epilogue.- References.

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