Overview

This guide is based on the synthesis of bisquinlone based phosphine ligands and desulfitative carbon-carbon bond forming reactions. It is divided into 3 chapters which include first an overview about heterocyclic BINAP analogues. In this chapter, survey of developing atropisomeric biheteroaryl backbone-containing bisphosphines, their designing concept, synthetic approaches and some of their important applications are discussed. Second, efficient synthesis of functionalized novel bisquinolone based mono- and diphosphine ligands of the aza-BINAP type. Preliminary studies confirm that these novel types of aza-BINAP phosphines containing an enamide moiety incorporated into the heteroaryl ring are indeed useful ligands in transition metal-catalyzed transformations. Third, palladium(0)- catalyzed, copper(I)-mediated desulfitative iC cross-coupling protocol (Liebeskind-Srogl type) of cyclic thioamides and thioureas with alkenylboronic acids, vinyl- and (het)arylstannanes, and arylsiloxanes is performed. These iC cross-couplings are a valuable extension of the traditional Liebeskind-Srogl reactions utilizing thioethers as electrophilic reagents.

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9783639256604

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