Overview

This book comparatively examines the etiopathogenetic, clinical-pathological, diagnostic and therapeutic strategies of the main bone tumors of domestic animals. The book also includes a description of the most significant aspects of macroscopic, microscopic, immunohistochemical, instrumental, diagnostic imaging and molecular biology aspects of spontaneous bone tumors in Veterinary Medicine, with also interspecies comparative aspects, including the human one. Last but not least, the book provides an overview of the new diagnostic and therapeutic frontiers related to the approach to animal bone tumors. The book serves as essential reading for professionals, researchers and students who work or want to tackle three paths in the field of comparative veterinary bone oncology.  

Full Product Details

Author:   Leonardo Leonardi
Publisher:   Springer Nature Switzerland AG
Imprint:   Springer Nature Switzerland AG
Edition:   1st ed. 2022
Weight:   0.489kg
ISBN:  

9783030902094

ISBN 10:   3030902099
Pages:   193
Publication Date:   21 December 2021
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Contents Preface CHAPTER 1: OUTLINE OF ANATOMY/PHYSIOLOGY OF SKELETAL TISSUES 1.         Structure and Physiology of Skeletal Tissue 1.1         Bone tissue 1.2         Bone cells 1.3         Bone tissue organization 1.4         Normal bone development 1.5         Types of skeletal tissues 1.6         Bone and cartilage as skeletal tissues 1.7         Functions of bone in the skeleton 1.8         Origin and dynamic functions of the skeleton and their origins 1.9         Ultrastructure of cells of the skeleton 1.10     Cells of skeleton derived from neural crest 1.11     Fibroblasts, fibrocytes and myofibroblasts in the skeleton 1.12     Monocytes, macrophages and histiocytes 1.13     Chondroblasts and chondrocytes 1.14      Osteoblasts, osteocytes and osteoclasts 1.15      Smooth muscle cells 1.16     Striated skeletal muscle cells 1.17     Lipoblasts and lypocytes 1.18     Angioblasts, vascular endothelium, pericites 1.19  Synovium 1.20  Mast Cells 1.21  Cells of neural crest origin   CHAPTER 2: TUMORS OF THE MUSCULOSKELETAL SYSTEM 2.1 Terminology 2.2 Abnormal growths discussed vs skeletal tumors 2.3 Benign vs malignant bone tumors 2.4 Cellular features: metaplasia and anaplasia 2.5 Tumor progression: last phase in tumor development 2.6 Predisposing conditions and genetic predisposition 2.7 Tumor site of origin defines tumor categories for osteosarcoma: 2.7.1 Periosteal origin: Periosteal, Parosteal and Surface osteosarcomas 2.7.2 Medullary origin: Intramedullary (syn, Intracortical)                    2.8 Introduction to tumors of bone                    2.9 WHO classification scheme for domestic animal bone tumors                    2.10 Tumors of bone in animals: categories, frequency and clinical behavior                    2.11 Benign tumors of bone                         2.11.a.  Osteoma: Clinical, radiographic, CT, MRI, and microscopic features                         2.11.b.  Osteoblastoma: Uncommon but features are described                         2.11.c.  Myxoma of jaw: Uncommon; clinical and histologic features are                                      described                         2.11.d.  Osteochondroma: Growth plate dysplasia; structural features are                                      described                         2.11.e.  Feline osteochondromatosis: C-retroviral periosteal progressive                                      growth                         2.11.f.  Chondroma of bone: Periosteal nodule with clinical & structural                                      features                         2.11.g.  Hemangioma of bone: Medullary vascular lesion with features                                      described                         2.11.h. Table comparing features of selected benign and malignant tumors                      2.12 Malignant tumors of bone                         2.12.a. Historical discussion: Spectrum of premalignant lesions, invasive but                                      non metastatic tumors, low-grade to highly malignant bone tumors                         2.12.b. Barriers to tumor expansion; tumor locations in a bone                         2.12.c. Osteosarcoma: Definition and pathogenesis                             2.12.c.1.  Central (syn. medullary, conventional and classic osteosarcoma):                                     Ultrastructure, staging, grading, genetic biomolecular information.                          Diagnostic features described for each example                                     Poorly differentiated                                     Osteoblastic: nonproductive and productive                                     Chondroblastic                                     Fibroblastic                                     Telangiectatic                                     Giant cell type                             2.12.c.2   Periosteal origin: Periosteal, Parosteal and Surface osteosarcomas                                     Etiology, radiographic, gross and histopathologic features described                                     Parosteal osteosarcoma is tumor arising on a bone surface, i.e., a                                         juxtacortical osteosarcoma                         2.12.d. Chondrosarcoma: Clinical, radiographic, gross, microscopic and                                    immunohistochemical staining features and a differential diagnosis are                                presented                                     Table compares: Low, intermediate and high-grade features                                     Flow diagram of malignant change from MSC to chondrosarcoma                         2.12.e. Fibrosarcoma: Clinical, gross, radiographic, microscopic findings and                                            differential diagnosis are presented.                                     List of 8 key diagnostic microscopic features for malignancy 2.12.f. Hemangiosarcoma: Clinical, gross, radiographic, microscopic findings        and differential diagnosis are presented                         2.12.g. Giant cell tumor of bone: Clinical, gross, radiographic, microscopic                                    findings and differential diagnosis are presented                                     List of 8 key diagnostic microscopic features for malignancy                         2.12.h. Multilobular tumor of bone                2.12.i.  Synovial sarcoma                         2.12.j.  Liposarcoma                         2.12.k. Malignant mesenchymoma 2.13     OTHERS UNCOMMON BONE TUMORS 2.13.1 Myxosarcoma 2.14 Tumors of bone marrow 2.14.1 Myeloma and multiple myeloma 2.14.2 Lymphoma   3.         TUMOR-LIKE LESIONS OF THE MUSCULOSKELETAL SYSTEM             3.1 Fibrous dysplasia             3.2 Solitary bone cyst: Clinical, gross, microscopic findings and differential diagnosis       are presented             3.3 Juxtacortical bone cyst: Lesions in animals are compared to those in man.             3.4 Epidermoid cyst of the phalanx: clinical, gross, microscopic findings and                                 differential diagnosis are presented             3.5 Myositis ossificans: This is a benign lesion that arises in the fascial planes of               muscle likely from mesenchymal stem cells provoked by trauma. It has                              characteristic tri-layer histologic features. Clinical, gross and histopathologic                     features are presented.             3.6 Villonodular synovitis of joints   4.         GENERAL CONSIDERATIONS ABOUT BONE TUMORS:             4.1 Primitive tumor index: T-index             4.2 Distant metastasis: M-index             4.3 Histologic grade: G-index             4.4 Staging index: I-III with substages and Table for man (Enneking, 1983) 4.5 Specimen selection, processing and histologic methods for evaluating bone specimens CHAPTER 5:  Appendix: Manual for histological preparation and examination of tissues containing bone and cartilage:             5.1 Importance of history, clinical findings, imaging interpretation from clinical                radiographs, angiography, nuclear bone scan, CT, MRI, ultrasound, needle                     aspiration and cytology, trochar biopsy, excisional biopsy, fixation,                            decalcification, embedment, sectioning, selection of histologic stains and                           immunohistochemical stains             5.2 Histologic examination while considering prior clinical and imaging                             information in making a diagnosis. 6.         References:1-630 7.         Acknowledgements

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Author Information

Dr. Leonardi's research is mainly focused on the study of spontaneous bone tumors and skeletal diseases in domestic animals. After years of morphological and immunohistochemical investigations in different types of primary bone tumors such as osteosarcoma and giant cell tumor of bone, the Dr. Leonardi is currently working on the biomolecular and comparative genetic characterization of animal and human spontaneous osteosarcomas.

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