Overview

What are bone morphogenetic proteins (BMPs) and how can they be used in orthopaedic practice? Ever since Urist proposed in 1976 that protein factors from cortical bone appeared to modulate bone healing in animals, there has been a search for these mysterious osteoinductive components. Now that their structure has been elucidated, they have been purified and cloned, and are now available for the improvement of bone healing. The best source of BMPs is demineralised bone. This bone allograft is used to achieve greater osteoinductive capacity. But are the actions procurement, processing, demineralisation and sterilisation harmful to the BMPs? Unless the BMPs can be assayed, neither their clinical nor their scientific effectiveness can be appraised. All these aspects are logically and scientifically described in this volume. In addition, there is a review of the biochemistry of one of the two main components of bone, namely collagen. This subject is itself a confusing but rapidly growing field. This comprehensive review describes the procedures for building up bone in vivo and in vitro. Bone Morphogenetic Proteins and Collagen answers most of the questions of orthopaedic surgeons and tissue bankers on how BMPs can be produced and used to their maximum effectiveness. Contents: From Bone Allografts to Synthetic Bone Grafts: Bone Morphogenetic Proteins and Osteoinduction; The Osteoinductive Properties of Demineralised Bone Matrix Grafts; Processing Factors Contributing to Production of Maximally Osteoinductive Demineralised Ground Bone; Clinical Effectiveness of Demineralised Bone Matrix Assayed in Human Cell Culture; The Influence of Sterilization on the Osteoinductive Properties of Bone inRat Bone Marrow Cell Culture; Collagen Biochemistry: An Overview. Readership: Orthopaedic

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?this series in allografts in bone healing: biology and clinical applications is a very commendable idea ??

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