Overview

The second edition of this book serves both as an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume describes the molecular and cellular mechanisms involved in the formation of bone metastases, presents the newer advances made in the understanding of the clinical picture and symptoms of patients, analyses the role of bone markers in research and clinical practice and deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases. Moreover, the use of all available treatment methods, such as radiotherapy, surgery and systemic treatments for the management of patients with metastatic bone disease is discussed in detail. Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for researchers, oncologists, orthopaedic surgeons and clinicians dealing with patients with metastatic bone disease.

Full Product Details

Author:   Vassilios Vassiliou ,  Edward Chow ,  Dimitrios Kardamakis
Publisher:   Springer
Imprint:   Springer
Edition:   2nd ed. 2014
Volume:   21
Dimensions:   Width: 15.50cm , Height: 3.30cm , Length: 23.50cm
Weight:   9.596kg
ISBN:  

9789400775688

ISBN 10:   9400775687
Pages:   490
Publication Date:   02 December 2013
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Preface. I Fundamental Concepts.- Pathophysiology of metastatic bone disease.- Bone metastases: epidemiology, clinical picture, SREs and prognosis.- Pain in bone metastases: types and mechanisms. II Investigations Of Bone Metastases.- Radiological evaluations: radiography, CT, MRI.- Nuclear medicine imaging modalities: bone scintigraphy, PET-CT, SPECT.- Bone turnover markers.- New omics approaches for bone metastases. III Therapeutic Management.- Analgesic treatment for bone mets.- Radiotherapy: external beam and radio-surgery.- Radionuclide therapy.- Bisphosphonates.- New targeted therapies for bone metastases.- Chemotherapy and hormone therapy.- HIFU/Radioablation.- Neuropathic bone metastases.- Spinal cord compression and cauda equina compression.- Pathological and impending fracture.- Re-irradiation.- Bone metastases in elderly patients.- Management of metastatic bone disease in the elderly with bisphosphonates and RANKL inhibitors: effectiveness and safety. IV Assesment of Therapeutic Response.- Radiological and nuclear medicine imaging modalities.- Clinical assessment measures.- Outcome measures in bone metastases clinical trials.- Quality of life in patients suffering from metastatic skeletal disease. V Cost of Managing Metastatic Bone Disease.- Cost effectiveness of treatment modalities for bone metastases.- Index.

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