Overview

This book describes succinctly the factors which affect the incorporation of massive and morsellised allografts after transplantation. Unless special precautions are taken, massive allografts when implanted can undergo stress fatigue. due to the limited incorporation at the graft-host interface. Immunological and cell signalling growth factors can be shown to greatly influencnce the behaviour of the graft. The bone-biological processes are illustrated in terms of demineralised bone, which can initiate bone induction due to the protection and availability of the original bone-morphogenic protein. The main message is that transplantation without consideration of the underlying biological healing processes can reduce the effectiveness of the procedure. Contents: The Biology of Massive Bone Allografts; Immunology of Bone Grafts: Current Knowledge; The Application of Growth Factors to Enhance Bone Healing; Biology of Healing of Large Deep-Frozen Cortical Bone Allografts; The Effect of Growth Factors on Bone Allografts; The Effect of Growth Factors on Bone Healing and the Clinical Applications of Autogenous Platelet-Rich Plasma Gel to Enhance Bone Formation; Biology of Demineralised Bone and Its Clinical Use. Readership: Orthopaedic surgeons who use tissue allografts in bone and related reconstructions.

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