Overview

This book provides a clinically oriented overview on the patho-physiological background and the use of bisphosphonates in oncology. The clinical development of pamidronate to treat tumor-induced hypercalcemia and malignant osteolytic bone disease is demonstrated, as well as the results of pivotal studies. New important findings on how to best use pamidronate in certain indications are given and put in perspective. The author discusses patient management guidelines as well as pharmaco-economic aspects important for the readers.

Full Product Details

Author:   Beat Thürlimann
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1999
Volume:   149
Dimensions:   Width: 15.50cm , Height: 0.70cm , Length: 23.50cm
Weight:   0.213kg
ISBN:  

9783642641480

ISBN 10:   3642641482
Pages:   113
Publication Date:   15 September 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Physiology and Pathophysiology of Bone.- Natural History of the Skeleton.- Cortical Bone.- Trabecular Bone.- Composition of Bone.- Bone Cells.- Factors Regulating Calcium Homeostasis and Bone Resorption/Bone Formation.- References.- Bone Resorption.- Mechanisms of Local Bone Resorption.- References.- Bone Formation.- Cells of the Osteoblast Lineage.- Osteocalcin.- Other Bone Matrix Proteins.- Bone Mineralization.- References.- Factors Regulating Bone-resorbing Cells and Bone-forming Cells.- Parathyroid Hormone.- Calcitonin.- Vitamin D3.- Prostaglandins.- Interleukin-1.- Tumor Necrosis Factor and Lymphotoxin.- Interleukin-4.- Interleukin-6.- ?-Interferon.- Colony-stimulating Factors.- Osteoclast-forming Factor.- References.- Factors Regulating Bone Formation.- Transforming Growth Factor ? (TGF- ?).- Fibroblast Growth Factors.- Platelet-derived Growth Factor.- Bone Morphogenetic Proteins.- Insulin-like Growth Factors.- References.- Pharmacological Treatment of Bone Disorders.- Estrogens and Antiestrogens.- Calcium.- Fluoride.- Vitamin D3/Calcitriol.- Phosphate Therapy.- References.- Bisphosphonates.- Pamidronate: From a Detergent in Washing Powder to a Registered Drug.- References.- Chemical Structure and Preclinical Evaluation.- Chemical Structure.- Biological Effects.- Pharmacokinetics.- Distribution.- References.- Hypercalcemia of Malignancy.- Magnitude of the Problem.- Pathogenesis.- Mediators.- Treatment.- Rehydration and Supportive Care.- Plicamycin (Mithramycin).- Dialysis.- Bisphosphonates.- Other Bisphosphonates.- Gallium Nitrate.- Cisplatin.- References.- Malignant Osteolytic Bone Disease.- Magnitude of the Problem.- Interdisciplinary Management.- Etidronate.- Oral Formulations of Second- and Third-generation Bisphosphonates.- References.- Pamidronate.-Pharmacokinetics of Pamidronate in Patients with Bone Metastases.- References.- Pamidronate for Pain Control in Patients with Malignant Osteolytic Bone Disease: A Prospective Dose-Effect Study.- Patients and Methods.- Results.- Discussion.- Conclusion.- References.- A Prospective, Randomized, Dose-finding Study of Pamidronate in Patients with Malignant Osteolytic Bone Disease.- Patients and Methods.- Statistical Analysis.- Results.- Patients Characteristics.- Properties of LASA Scales and PSC.- Efficacy (LASA).- Efficacy (PS, PSC, and Use of Analgesics).- Efficacy (Laboratory Values).- Treatment Duration.- Toxicity and Side Effects.- Multivariate Analysis.- Conclusion.- References.- Pamidronate Versus Controls in Patients with Metastatic Breast Cancer and Bone Metastases.- Pamidronate for Inhibition of Bone Progression in Patients with Advanced Breast Cancer: A Randomized, Multicenter Phase-III Trial.- Patients and Methods.- Results.- Discussion.- References.- Aredia in the Indication of Osteolytic Bone Metastases of Breast Cancer: A Model for Evaluation of Cost-Benefit.- References.- Prospective, Randomized, Double-blind, Dose-finding Study in Patients with Malignant Osteolytic Bone Metastases and Pain: 60 mg vs. 90 mg Pamidronate.- Aim of the Study.- Study Design.- Treatment.- Statistical Considerations.- Patient Characteristics.- Results.- Pain Intensity.- Responders/Nonresponders.- Pain Improvement.- Pain Frequency.- General Well-being.- Pain Score.- Performance Status.- Analgesic Score.- Total Bone Mineral Density.- Correlation of Results from Selected End Points.- Pain Intensity and Bone Mineral Density.- Correlation of Bone Mineral Density and Diagnosis.- Discussion.- References.- Cost-Effectiveness Analysis of Pamidronate Treatment in Patients with Advanced Malignant Osteolytic Bone Disease: SG 110/93 Plus.- Patients and Methods.- Results.- Conclusion.- Recent Developments and Future Directions.- Ibandronate.- Pamidronate.- Adjuvant Bisphosphonate Therapy.- Future Directions.- References.

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