Overview

An international team of investigators presents thought-provoking reviews of bioreactors for stem cell expansion and differentiation and provides cutting-edge information on different bioreactor systems. The authors offer novel insights into bioreactor-based culture systems specific for tissue engineering, including sophisticated and cost-effective manufacturing strategies geared to overcome technological shortcomings that currently preclude advances towards product commercialization. This book in the fields of stem cell expansion, bioreactors, bioprocessing, and bio and tissue engineering, gives the reader a full understanding of the state-of-art and the future of these fields. Key selling features: Describes various bioreactors or stem cell culturing systems Reviews methods for stem cell expansion and differentiation for neural, cardiac, hemopoietic, mesenchymal, hepatic and other tissues cell types Distinguishes different types of bioreactors intended for different operational scales of tissue engineering and cellular therapies Includes contributions from an international team of leaders in stem cell research

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9781498795906

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Joaquim M.S. Cabral is a Professor of Biological Engineering, in the Department of Bioengineering at Instituto Superior Técnico (IST), University of Lisbon, Portugal. He is the founding head of department and director of the Institute for Bioengineering and Biosciences. Joaquim Cabral's research focuses on novel developments in bioprocess engineering and stem cell bioengineering. His research includes stem cell bioprocessing and manufacturing, addressing the ex-vivo expansion, controlled differentiation and purification of hematopoietic stem cells, mesenchymal stem cells, and pluripotent stem cells (both ESC and iPSC). Claudia Lobato da Silva is an Assistant Professor in the Department of Bioengineering, Instituto Superior Técnico, University of Lisbon, Portugal. Her research interests involve the development of novel methods to isolate and purify stem cells, and establish optimal conditions for the maximization of expansion of umbilical cord blood-derived hematopoietic stem/progenitor cells, as well as developing bioreactor strategies for the clinical-scale production of mesenchymal stem/stromal cells from different human sources.

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