Overview

Rapid advances in the study of the molecular basis of mammalian cell proliferation, differentiation, and apoptosis have made it possible to develop new screening systems for isolating from microbial metabolites specific inhibitors of mammalian cell functions. Bioprobes is the term used to describe these inhibitors, which are extremely useful agents in investigating the molecular and chemical regulation of eukaryotic cell function and apoptosis. Another area where bioprobes are playing an important role is research into immune cell function. This book is the first to present the groundbreaking applications of bioprobes as tools for biochemical research. A large appendix contains the chemical structure, origin, function, key references, and other essential data for more than 80 important bioprobes. The information for each bioprobe is shown in a two-page display, in an easy-to-use format for identifying specific bioprobes for investigation of cell function.

Full Product Details

Author:   H. Osada
Publisher:   Springer Verlag, Japan
Imprint:   Springer Verlag, Japan
Edition:   Softcover reprint of the original 1st ed. 2000
ISBN:  

9784431659297

ISBN 10:   4431659293
Pages:   319
Publication Date:   15 May 2001
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

1 Trends in Bioprobe Research.- 1 Introduction.- 2 Sources of Bioprobes.- 3 Development of Bioprobes.- 4 Targets for Bioprobes.- 5 Trends and Prospects.- References.- 2 Cell Proliferation: From Signal Transduction to Cell Cycle.- 1 Introduction.- 2 Membrane/Cytoplasmic Signal Transduction.- 3 Nuclear Signal Transduction.- 4 Cell Cycle Control.- 5 Future Prospects.- References.- 3 Differentiation.- 1 Introduction.- 2 Differentiation of Hematopoietic Cells.- 3 Differentiation of Neuron Cells.- 4 Differentiation of Skeletal Cells (Bone and Muscle Cells).- 5 Differentiation of Liver: Hepatocytes.- 6 Epidermal Differentiation.- References.- 4 Apoptosis.- 1 Introduction.- 2 Tyrosine Kinase.- 3 Ceramide Synthesis.- 4 Fas Signaling.- 5 c-Jun NH2-Terminal Kinase.- 6 Cyclooxygenase-2.- 7 Calmodulin-Dependent Kinase III.- 8 PI-3 Kinase-Akt.- 9 Cell Cycle Regulator.- 10 p53.- 11 Hydroxymethyl Glutaryl CoA Reductase.- References.- 5 Immune Cell Functions.- 1 Introduction: Immune Network.- 2 Bioprobes for Lymphocyte Proliferation.- 3 Signal Transduction and Gene Expression in the Process of T Cell Activation.- 4 Cell-Mediated Cytotoxicity and Its Bioprobes.- 5 Conclusions.- References.- 6 Bioprobes at a Glance.- Authors and Collaborators.

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