Biophysical Techniques in Drug Discovery

Author:   Angeles Canales (Universidad Complutense de Madrid, Spain) ,  Andrew Scott (Sygnature Discovery, UK) ,  Ana Martinez (Centro de Investigaciones Biologicas-CSIC, Spain) ,  Mari Jean Eggen (Eli Lilly and Company, USA)
Publisher:   Royal Society of Chemistry
Volume:   Volume 61
ISBN:  

9781782627333


Pages:   320
Publication Date:   20 November 2017
Format:   Hardback
Availability:   In Print   Availability explained
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Biophysical Techniques in Drug Discovery


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Overview

Biophysical techniques are used in many key stages of the drug discovery process including in screening for new receptor ligands, in characterising drug mechanisms, and in validating data from biochemical and cellular assays. This book provides an overview of the biophysical methods applied in drug discovery today, including traditional techniques and newer developments. Perspectives from academia and industry across a spectrum of techniques are brought together in a single volume. Small and biotherapeutic approaches are covered and strengths and limitations of each technique are presented. Case studies illustrate the application of each technique in real applied examples. Finally, the book covers recent developments in areas such as electron microscopy with discussions of their possible impact on future drug discovery. This is a go-to volume for biophysicists, analytical chemists and medicinal chemists providing a broad overview of techniques of contemporary interest in drug discovery.

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Author:   Angeles Canales (Universidad Complutense de Madrid, Spain) ,  Andrew Scott (Sygnature Discovery, UK) ,  Ana Martinez (Centro de Investigaciones Biologicas-CSIC, Spain) ,  Mari Jean Eggen (Eli Lilly and Company, USA)
Publisher:   Royal Society of Chemistry
Imprint:   Royal Society of Chemistry
Volume:   Volume 61
Weight:   0.653kg
ISBN:  

9781782627333


ISBN 10:   1782627332
Pages:   320
Publication Date:   20 November 2017
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print   Availability explained
This item will be ordered in for you from one of our suppliers. Upon receipt, we will promptly dispatch it out to you. For in store availability, please contact us.

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Reviews

The techniques highlighted in this volume are introduced with concise theoretical background that prepares the reader for subsequent illustrative examples from the literature. The theoretical and methodological information is rather limited, but the reader is directed to useful references for further reading. This book will be helpful for medicinal, synthetic, and biophysical chemists urveying an array of tools for their specific drug discovery projects, especially to those who do not want to be inundated with theoretical details. Even though most chapters in this book are written in a manner suitable for an audience with intermediate to advance knowledge of biophysics, Chapter1 will pique the interest of beginners in the field, and is a nice introductory reading for medicinal chemistry graduate students, as it provides a historical perspective and overview of biophysical techniques used at various phases of the drug discovery workflow, namely, hit generation, validation, and drug structure optimization. -- Professor Ian Mitchelle de Vera, Saint Louis University School of Medicine, USA * DOI: 10.1002/cmdc.201800207 *


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