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Author:   Angeles Canales (Universidad Complutense de Madrid, Spain) ,  Mari Jean Eggen ,  Juan Felix Espinosa ,  Oscar Millet
Publisher:   Royal Society of Chemistry
Imprint:   Royal Society of Chemistry
Volume:   Volume 61
Weight:   0.653kg
ISBN:  

9781782627333

ISBN 10:   1782627332
Pages:   336
Publication Date:   20 November 2017
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Impact and Evolution of Biophysics in Medicinal Chemistry; Ligand-Detected NMR Methods in Drug Discovery; Receptor based NMR techniques in Drug Discovery; Molecular Mechanisms of Drug Action: X-ray Crystallography at the Basis of Structure-based and Ligand-based Drug Design; Mass Spectrometry in Biophysics: from High Throughput Screening to Structural Biology; Characterization of Pharmaceutical Solids Combining NMR, X-ray Diffraction and Computer Modelling; Surface Plasmon Resonance for Identifying and Characterising Small Molecule Ligands; Fluorescent Thermal Shift Assays for Identifying Small Molecule Ligands; Fluorescent Probes in Medicinal Chemistry; Transmission Cryo-Electron Microscopy in Drug Discovery; Molecular Imaging; Subject Index

Reviews

The techniques highlighted in this volume are introduced with concise theoretical background that prepares the reader for subsequent illustrative examples from the literature. The theoretical and methodological information is rather limited, but the reader is directed to useful references for further reading. This book will be helpful for medicinal, synthetic, and biophysical chemists urveying an array of tools for their specific drug discovery projects, especially to those who do not want to be inundated with theoretical details. Even though most chapters in this book are written in a manner suitable for an audience with intermediate to advance knowledge of biophysics, Chapter1 will pique the interest of beginners in the field, and is a nice introductory reading for medicinal chemistry graduate students, as it provides a historical perspective and overview of biophysical techniques used at various phases of the drug discovery workflow, namely, hit generation, validation, and drug structure optimization. -- Professor Ian Mitchelle de Vera, Saint Louis University School of Medicine, USA * DOI: 10.1002/cmdc.201800207 *

The techniques highlighted in this volume are introduced with concise theoretical background that prepares the reader for subsequent illustrative examples from the literature. The theoretical and methodological information is rather limited, but the reader is directed to useful references for further reading. This book will be helpful for medicinal, synthetic, and biophysical chemists urveying an array of tools for their specific drug discovery projects, especially to those who do not want to be inundated with theoretical details. Even though most chapters in this book are written in a manner suitable for an audience with intermediate to advance knowledge of biophysics, Chapter1 will pique the interest of beginners in the field, and is a nice introductory reading for medicinal chemistry graduate students, as it provides a historical perspective and overview of biophysical techniques used at various phases of the drug discovery workflow, namely, hit generation, validation, and drug structure optimization. * DOI: 10.1002/cmdc.201800207 *

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