Overview

This book provides a premier resource on understanding the ribosome's essential nature and how it interacts with other proteins and nucleic acids to control protein synthesis. As one of the central foundations in our understanding of the biology at the molecular level, this topic appeals to a wide audience, from bench researcher to clinician.  With the advent of atomic scale structures, methods to visualize and separate individual molecules, and the computational power to model the complex interactions of over a million atoms at once, our understanding of how gene expression is controlled at the level of protein translation is now deeply ensconced in the biophysical realm.

Full Product Details

Author:   Jonathan D. Dinman
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   2013 ed.
Volume:   1
Dimensions:   Width: 15.50cm , Height: 2.30cm , Length: 23.50cm
Weight:   0.664kg
ISBN:  

9781461439905

ISBN 10:   1461439906
Pages:   320
Publication Date:   20 September 2012
Audience:   College/higher education ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

X-ray analysis of prokaryotic and eukaryotic ribosomes.- A passage through the ribosome by Cryo-EM.- Molecular dynamics simulations of the ribosome.- Structural analyses of the ribosome by chemical modification methods.- Methods for studying the interactions of translation factors with the ribosome.- Riboproteomic approaches to understanding IRES elements.- Rapid kinetic analysis of protein synthesis.- Investigating RNAs Involved in Translational Control by NMR and SAXS.- Analyses of RNA-ligand interactions by fluorescence anisotropy.- Approaches for the Identification and Characterization of RNA-Protein Interactions.- A multidisciplinary approach to RNA Localization.- Virtual Screening for RNA-interacting Small Molecules.- The ‘fifth’ RNA nucleotide: a role for ribosomal RNA pseudouridylation in control of gene expression at the translational level.- Translational Control of Synaptic Plasticity and Memory.

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