Overview
Bone is a dynamic tissue that undergoes continual adaptation during vertebrate life to preserve skeletal size, shape, and structural integrity and to regulate mineral homeostasis. Bone mass is skilfully regulated through osteoclasts and osteoblasts. Bone mass is reduced through decreased osteoblastic bone formation and increased osteoclastic bone resorption. This decrease induces osteoporosis. Bone loss is also caused in various pathophysiologic states including inflammatory condition, obesity, diabetes, and cancer cell bone metastasis. In addition, malnutrition or undernutrition is often observed with increasing ages and is strongly implicated in the pathogenesis and consequences of bone fracture in the osteoporotic elderly. Nutritional and functional food factors may play a pivotal role in maintaining bone health, and this will be expected as a new biomedical treatment for osteoporosis.
Full Product Details
Author: Masayoshi Yamaguchi, Ph.D., IOM, FAOE, DDG, DG
Publisher: Nova Science Publishers Inc
Imprint: Nova Science Publishers Inc
Weight: 0.512kg
ISBN: 9781628087451
ISBN 10: 1628087455
Pages: 194
Publication Date: 01 December 2013
Audience:
Professional and scholarly
,
Professional & Vocational
Format: Hardback
Publisher's Status: Active
Availability: Available To Order
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Author Information
Masayoshi Yamaguchi, Ph.D., IOM, FAOE, DDG, DG, is Adjunct Professor, Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA (2013 - ). Dr. Yamaguchi is engaged in the fields of endocrinology and cell signaling since 1971, and these researches are developed in the aspect of biochemistry, molecular biology, endocrinology, metabolism, nutrition, pharmacology, and toxicology. Dr Yamaguchi has an interesting for cell signaling mechanism, bone biology, nutritional factor and osteoporosis prevention, diabetes and diabetic osteoporosis, cancer biology, and cancer cell bone metastasis. Dr. Yamaguchi discovered two novel proteins and genes; cell signaling suppressor protein (named regucalcin; 1978) and transcriptional factor RGPR-p117 (regucalcin gene promoter region-related protein; 2001). Dr Yamaguchi generated regucalcin transgenic rats, which were registered as international patents including USA, EU and Japan, and this animal was found to induce osteoporosis and hyperlipidemia. Moreover, Dr. Yamaguchi proposed the potential role of regucalcin as a key suppressor protein in carcinogenesis. Thus far, Dr Yamaguchi published over 550 English articles to professional journals with peer-review, and registered over 20 national and international patents.
