Overview

This volume provides detailed technical protocols on current biomedical technologies and examples of their applications and capabilities. Chapters focus on molecular and cellular analytical methods, experimental new drug delivery approaches, guided surgery, implants and tissue engineering.     Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols.   Authoritative and practical, Biomedical Engineering Technologies, Volume 2 provides technical details in descriptions of major technologies by experts in the field.

Full Product Details

Author:   Avraham Rasooly ,  Houston Baker, Jr. ,  Miguel R. Ossandon
Publisher:   Springer-Verlag New York Inc.
Imprint:   Springer-Verlag New York Inc.
Edition:   1st ed. 2022
Volume:   2394
Weight:   1.746kg
ISBN:  

9781071618134

ISBN 10:   107161813
Pages:   910
Publication Date:   01 February 2023
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

Part I: Molecular and Cellular analysis and manipulation  1. Development of a Multi-Target Protein Biomarker Assay for Circulating Tumor Cells  Diya Li, Ceming Wang, Yingjia Ni, Yaoping Liu, Wei Wang, Siyuan Zhang, Hsueh-Chia Chang, and Satyajyoti Senapati   2. Method to Isolate Dormant Cancer Cells from Heterogeneous Populations Julian A. Preciado, and Alptekin Aksan   3. Label-Free Morphological Phenotyping of in vitro 3D Micro Tumors Zoe Moscato, Devina Jaiswal, Krishna Dixit, Cooper J. Langanis, Kevin P. Claffey, and Kazunori Hoshino   4. High-throughput microenvironment microarray (MEMA) (file #high-resolution imaging Tiina A Jokela, Michael E Todhunter, and Mark A LaBarge   5. Real-Time Analysis of AKT Signaling Activities at Single-Cell Resolution Using Cyclic Peptide-Based Probes Fei Ji, Siwen Wang, Shiqun Shao, Priyanka Sarkar, and Min Xue   6. Microfluidic device technologies for digestion, disaggregation, and filtration of tissue samples for single cell applications Jeremy A. Lombardo, and Jered B. Haun   7. Microdissection methods utilizing single cell subtype analysis and the impact on precision medicine Donald J. Johann, Jr., Sarah Laun, Owen Stephens, Robert Weigman, , Ikjae Shin, , Adam Roberge, Meeiyueh Liu, Valerie Greisman, Mathew Steliga, Jason Muesse, , Erich Peterson, , Michael R. Emmert-Buck and Michael A. Tangrea,   8. Functionalized lineage tracing for the study and manipulation of heterogeneous cell populations Andrea Gardner, Daylin Morgan, Aziz Al’Khafaji, and Amy Brock   9. Fluorescence lifetime imaging probes for cell-based measurements of enzyme activity Sampreeti Jena, and Laurie L. Parker   10. Assessment of intracellular GTP levels using genetically encoded fluorescent sensors’ Anna Bianchi-Smiraglia, and Mikhail. Nikiforov   11. Node-Pore Sensing for characterizing cells and extracellular vesicles Thomas Carey, Brian Li, and Lydia L. Sohn   12. Affinity-Based Enrichment of Extracellular Vesicles with Lipid Nanoprobes Yuan Wan, Mackenzie Maurer, and Si-Yang Zheng   13. Droplet magnetofluidic assay platform for quantitative methylation-specific PCR  Alejandro Stark, Alexander Trick, Thomas R Pisanic II, and Tza-Huei Wang 14. Droplette: A Platform Technology to Directly Deliver Nucleic Acid Therapeutics and Other Molecules into Cells and Deep into Tissue Without Transfection Reagents Bao Lin Quek, Rathi L Srinivas, and Madhavi P Gavini   15. Molecular imaging of HER2 in patient tissues with touch prep-quantitative single molecule localization microscopy Devin L. Wakefield, Steven J. Tobin, Daniel Schmolze, and Tijana Jovanovic-Talisman   16. Microchip free-flow electrophoresis for bioanalysis, sensing and purification William E. Arter, Kadi L. Saar, Therese W. Herling, and Tuomas P. J. Knowles   17. Green Chemistry Preservation and Extraction of Biospecimens for Multi-omic Analyses Andrey P. Tikunov, Jeremiah D. Tipton, Timothy J. Garrett, Sachi V. Shinde, Hong Jin Kim, David A. Gerber, Laura E. Herring, Lee M. Graves, and Jeffrey M. Macdonald   18. TdT-UTP DSB End Labeling (TUDEL), for Specific, Direct in situ Labeling of DNA Double Strand Breaks  Julian Lutze, Sara E Warrington, and Stephen J. Kron   19. Ligand-directed GPCR Antibody Discovery  Qi Zhao, Amanda Chapman, Yan Huang, Mary Ferguson, Shannon McBride, Meghan Kelly, Michael Weiner, and Xiaofeng Li   20. Self-Induced Back-Action Actuated Nanopore Electrophoresis (Sane) (File #Sensor For Label-Free Detection Of Cancer Immunotherapy-Relevant Antibody-Ligand Interactions Sai Santosh Sasank Peri, Muhammad Usman Raza, Manoj K. Sabnani, Soroush Ghaffari, Susanne Gimlin, Debra D. Wawro, Jung Soo Lee, Min Jun Kim, Jon Weidanz, and George Alexandrakis   21. Incorporating, quantifying, and leveraging noncanonical amino acids in yeast Jessica T. Stieglitz, and James A. Van Deventer   22. Nuclease-assisted, multiplexed minor-allele enrichment: application in liquid biopsy of cancer Fangyan Yu, Ka Wai Leong, and G. Mike Makrigiorgos   23. Implementation of Ion Mobility Spectrometry-Based Separations in Structures for Lossless Ion Manipulations (SLIM) Adam L. Hollerbach, Christopher R. Conant, Gabe Nagy, and Yehia M. Ibrahim   24. Pleural Effusion Aspirate for use in 3D Lung Cancer Modeling and Chemotherapy Screening Andrea Mazzocchi, Anthony Dominijanni, and Shay Soker   25. Using Optical Tweezers to Dissect Allosteric Communication Networks in Protein Kinases Yuxin Hao and Rodrigo Maillard   Part II: Therapeutics Technologies 26. Focused ultrasound-mediated intranasal brain drug delivery technique (FUSIN)  Dezhuang Ye, and Hong Chen 27. Extracellular pH mapping as therapeutic readout of drug delivery in glioblastoma John J. Walsh, and Fahmeed Hyder   28. Charge-Based Multi-Arm Avidin Nano-construct as a Platform Technology for Applications in Drug Delivery Tengfei He, Chenzhen Zhang, and Ambika G. Bajpayee   29. Chemical Modification of Proteins and Their Intracellular Delivery Using Lipidoid Nanoparticles Yamin Li, Zachary Glass, and Qiaobing Xu   30. Generation of Membrane-derived Nanovesicles by Nitrogen Cavitation for Drug Targeting Delivery and Immunization Jin Gao, Mindy Lee, Xinyue Dong, and Zhenjia Wang   31. Laboratory-scale production of sterile targeted microbubbles Guixin Shi, and Yu-Tsueng Liu   32 (file #47). Adeno-associated viral vector immobilization and local delivery from bare metal surfaces. Ben B. Pressly, Bahman Hooshdaran, Ivan S. Alferiev, Michael Chorny, Robert J. Levy, and Ilia Fishbein   33. Decellularization and Recellularization Methods for Avian Lungs: An Alternative Approach for Use in Pulmonary Therapeutics Alicia E. Tanneberger, Daniel J. Weiss, and Juan J.  Uriarte   34. Methods for Forming Human Lymphatic Microvessels In Vitro and Assessing Their Drainage Function Joe Tien, and Usman Ghani   35. Natural Polymer Based Micro-Nanostructured Scaffolds for Bone Tissue Engineering Sara Katebifar, Devina Jaiswal, Michael R. Arul, Sanja Novak, Jonathan Nip, Ivo Kalajzic, Swetha Rudraiah, and Sangamesh G. Kumbar   36. Biodegradable electrospun nanofibrous scaffolds for bone tissue engineering Aneela Anwar, Daniel Jerome Petrino Jr., Nicole Van Alstine, and Xiaojun Yu   37. Bio-Tribometer for the Assessment of Cell and Tissue Toxicity of Orthopedic Metal Implant Debris Simona Radice, and Markus A. Wimmer   38. Methods for Quantifying Neutrophil Extracellular Traps on Biomaterials Allison E. Fetz, William E. King III, Benjamin A. Minden-Birkenmaier, and Gary L. Bowlin   39. In Vivo Imaging of Implanted Hyaluronic Acid Hydrogel Biodegradation Shreyas Kuddannaya, Wei Zhu, and Jeff W.M. Bulte   40. Computational modeling and simulation to quantify the effects of obstructions on the performance of ventricular catheters used in hydrocephalus treatment Stephanie C. TerMaath, Douglas L. Stefanski, and James A. Killeffer   41. Selection of Cancer Stem Cell--targeting Agents Using Bacteriophage Display Austin R. Prater, and Susan L. Deutscher   42. Nano-Scintillator-Based X-Ray Induced Photodynamic Therapy Benjamin Cline, and Jin Xie   43. Methods to measure the inhibition of ABCG2 transporter and ferrochelatase activity to enhance aminolevulinic acid-protoporphyrin IX fluorescence-guided tumor detection and resection  Matthew Mansi, Richard Howley, and Bin Chen   44. Macroscopic Fluorescence Lifetime Imaging for Monitoring of Drug-Target Engagement Marien Ochoa, Alena Rudkouskaya, Jason T. Smith, Xavier Intes, and Margarida Barroso   45. Tumor in vivo Imaging with a New Peptide-based Fluorescent Probe Samer Naffouje, Masahide Goto, Ingeun Ryoo, Albert Green, Tapas K. Das Gupta, and Tohru Yamada   46. Thermal Ablation Treatment for Cervical Precancer (Cervical Intraepithelial Neoplasia grade 2 or higher [CIN2+]) Montserrat Soler, Rachel Masch, Rakiya Saidu, and Miriam Cremer   47. Employing Novel Porcine Models of Subcutaneous Pancreatic Cancer to Evaluate Oncological Therapies Alissa Hendricks-Wenger, Margaret A Nagai-Singer, Kyungjun Uh, Eli Vlaisavljevich, Kiho Lee, and Irving C Allen

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