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Author:   Paul F. Torrence (Northern Arizona University, Flagstaff, Arizona)
Publisher:   John Wiley & Sons Inc
Imprint:   Wiley-Interscience
Dimensions:   Width: 16.40cm , Height: 2.70cm , Length: 24.30cm
Weight:   0.789kg
ISBN:  

9780471326335

ISBN 10:   047132633
Pages:   432
Publication Date:   02 February 2000
Audience:   College/higher education ,  Undergraduate
Format:   Hardback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

DRUG DISCOVERY AND DEVELOPMENT LEADS FROM FUNDAMENTALS OF ENZYME TRANSFORMATIONS AND MECHANISMS. Sleeping Sickness: Irreversible Inhibitors of S-Adenosylmethionine Decarboxylase as Antitrypanosomal Agents (P. Woster). Mechanism-Based S-Adenosyl-L-Homocysteine Hydrolase Inhibitors in the Search For Broad-Spectrum Antiviral Agents (D. Yin, et al.). Alcoholism: Aldehyde Dehydrogenase Inhibitors as Alcohol Deterrent Agents (H. Nagasawa, et al.). AIDS: Adenosine Deaminase-Activated Prodrugs for the Treatment of Huamn Immunodeficiency Virus in the Central Nervous System (J. Driscoll). Anti-HIV Phosphotriester Pronucleotides: Basis for the Rational Design of Biolabile Phosphate Protecting Groups (C. Perigaud, et al.). EXPLORATION OF FUNDAMENTAL CHEMICAL PRINCIPLES IN DRUG DESIGN AND DISCOVERY. AIDS: Potential Inhibitors of Human Immunodeficiency Virus Replication (G. Kenyon). From Chemical Warfare Agent to Anticancer Drug: The Chemistry of Phosphoramide Mustard (S. Ludeman). Phosphoryltyrosyl Mimetics as Signaling Modulators and Potential Antitumor Agents (T. Burke, et al.). Targeting Tumors Using Magnetic Drug Delivery (S. Pulfer & J. Gallo). Cancer: Superacid Generation of New Antitumor Agents (J.-C. Jacquesy & J. Fahy). Fluorine Substitution as a Modulator of Biological Processes (K. Kirk). UNDERSTANDING THE CHEMICAL BASIS OF DRUG ACTION AND DISEASE. Thiouracil and Related Thioureylene Compounds as Melanoma-Seekers: Paradigms for a Chemical Approach to the Design of Targeting Anticancer Agents (M. d'Ischia & G. Prota). Carbon-Centered Radicals and Rational Design of New Antimalarial Peroxide Drugs (G. Posner, et al.). The Chemistry of Parkinson's Disease (G. Dryhurst, et al.). NOVEL CHEMISTRIES IN THE VANGUARD OF BIOTECHNOLOGY AND DRUG DISCOVERY. New Generation of DNA Chips Based on Real-Time Biomimetic Recognition (F. Garnier). Peptide Nucleic Acids (PNA): Towards Gene Therapeutic Drugs (P. Nielsen). Ribozyme Mimics: The Evolution of Gene-Specific Chemotherapy (T. Osiek, et al.). Index.

Reviews

Explains the application of chemistry to drug discovery and determination of disease etiology...provides an understanding of how fundamental chemical concepts are used... (SciTech Book News, March 2001) At what must be considered a modest price, this book is warmly recommended as a good overall survey of the field to chemists and biochemists working in biomedical or related areas. It will also appeal to teachers of organic chemistry as a source book of medically relevant example... (Journal of the American Chemical Society, Vol. 123, No. 30, 2001) In an age of disposable artifacts and useless gadgets, this is a book to pick up frequently, read slowly, assimilate, and above all enjoy. (Pharmaceutical Research, Vol. 18, No. 9, September 2001) A fascinating book...one of the best summaries of the new approach that I have seen. (Chemistry & Industry, 19 November, 2001) ...an essential handbook... (Journal of Natural Products, 2003)

Explains the application of chemistry to drug discovery and determination of disease etiology... (SciTech Book News, March 2001) A fascinating book...one of the best summaries of the new approach that I have seen. (Chemistry & Industry, 19 November, 2001) ...an essential handbook... (Journal of Natural Products, 2003)

Author Information

PAUL F. TORRENCE, PhD, is Professor and Chair of Chemistry at Northern Arizona University in Flagstaff, and formerly Chief of the Biomedical Chemistry Section, Laboratory of Medicinal Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, and Director of the Foundation for Advanced Education in the Sciences Graduate School at the National Institutes of Health. Dr. Torrence is widely recognized for his contributions to medicinal chemistry and has published more than 190 scientific papers and patents.

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