Overview

Biological markers used to assess the effects of environmental pollution have attracted considerable attention from regulatory agencies and are currently under evaluation at a number of research facilities throughout the world. However promising a biomarker-based biomonitoring approach may be, the development of this concept is complicated by a range of technical issues. This book provides a conceptional framework for research and application of biomarkers. International experts on biomonitoring have formulated a unified strategy for the development and validation of biomarkers in assessing environmental health as well as appropriate protocols for their implementation and interpretation in a biological monitoring program.

Full Product Details

Author:   David B. Peakall ,  Lee R. Shugart
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   Softcover reprint of the original 1st ed. 1993
Volume:   68
Dimensions:   Width: 17.00cm , Height: 1.30cm , Length: 24.20cm
Weight:   0.267kg
ISBN:  

9783642846335

ISBN 10:   3642846335
Pages:   119
Publication Date:   15 December 2011
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Active
Availability:   Manufactured on demand  
We will order this item for you from a manufactured on demand supplier.

Table of Contents

1. Applications and Objectives of Biomarker Research.- 1.1. Introduction.- 1.2. Definitions.- 1.3. Objectives of Biomarker Programs.- 1.4. Applications of Biomarker Programs.- 1.5. Rationale for the use of Biomarkers.- 1.6. Current Limitations in the use of Biomarkers.- 1.7. Future of Biomarkers in Environmental Assessment.- 1.8. Literature Cited.- 2. The Conceptual Basis of the Biomarker Approach.- 2.1. Introduction.- 2.2. Dose-Response Relationships.- 2.3. Physiological Alterations as a Basis for Biomarkers.- 2.4. Considerations in the use of Biomarkers.- 2.5. Future Prospects.- 2.6. Literature Cited.- 3. Implementation of Biomarker-Based Studies.- 3.1. Introduction.- 3.2. Selection and Characterization of Study Sites.- 3.3. Selection of Species.- 3.4. Biomarker Selection.- 3.5. Sampling Methodology.- 3.6. Analysis.- 3.7. Summary.- 3.8. Literature Cited.- 4. Interpretation of Biomarker Responses.- 4.1. Introduction.- 4.2. Biological Interpretation of Biomarkers.- 4.3. Statistical and Mathematical Techniques for Interpretation.- 4.4. Societal Interpretations.- 4.5. Literature Cited.- 5. Development and Validation of Biomarkers.- 5.1. Introduction.- 5.2. The Ideal Biomarker.- 5.3. Development of new Biomarkers.- 5.4. Validation.- 5.5. Literature Cited.- 6. Conceptual Strategy for Development and Application of a Biomarker-Based Biomonitoring Program.- 6.1. Definition of Study Objectives.- 6.2. General Elements of a Biomarker-Based Biomonitoring Study.- 6.3. Tailoring Study Design for Specific Objectives.- 6.4. Development of Biomarkers: Laboratory and Field Studies.- 6.5. Literature Cited.

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