Overview
The pharmaceutical industry has faced many significant challenges since the early 1990s. The fundamental issue that needs to be addressed is how to improve the efficiency of drug discovery and development. The current research and development (R&D) cost for developing a new therapeutic drug is greater than $800 million. Additionally, it takes an average of 12 years to get a new drug to market with an attrition rate greater than 90%. Reviewing the overall pharmaceutical R&D process, it has become clear that many of the drug failures are due to our lack of knowledge in population diversity, which is responsible for differences in drug efficacy and toxicity. In fact, not a single approved drug is 100% safe and efficacious for all patients. For researchers, the key question is: How can we discover biomarkers that can be used to distinguish patients who will respond to the drug without adverse effects from those who will not respond and/or will have adverse effects? There is tremendous urgency to address this question. Biomarkers also fit perfectly with the vision of personalized medicine, the new expectation of medical practice. This is why biomarker research has been a central focus in many research labs across academia, government agencies, and the pharmaceutical industry. There are many different ways to define biomarkers based on molecular properties, applications, and methods.
Full Product Details
Author: Feng Wang
Publisher: Humana Press Inc.
Imprint: Humana Press Inc.
Edition: Softcover reprint of hardcover 1st ed. 2008
Dimensions:
Width: 15.50cm
, Height: 2.10cm
, Length: 23.50cm
Weight: 0.646kg
ISBN: 9781617379253
ISBN 10: 1617379255
Pages: 396
Publication Date: 09 November 2010
Audience:
Professional and scholarly
,
Professional & Vocational
Format: Paperback
Publisher's Status: Active
Availability: In Print
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Reviews
"From the reviews: ""... extremely useful to pharmaceutical scientists who are involved in research all the way from early drug discovery through clinical trials."" - Doody's Book Review ""The book is ! for the bench scientist and is full of helpful advice on how to achieve high quality data using up-to-date technical approaches in genomics, proteomics and metabonomics. ! I warmly recommend this ! to all practicing toxicologists."" (Roy Forster, British Toxicological Society Newsletter, June-August, 2009)"
From the reviews: ... extremely useful to pharmaceutical scientists who are involved in research all the way from early drug discovery through clinical trials. - Doody's Book Review The book is ! for the bench scientist and is full of helpful advice on how to achieve high quality data using up-to-date technical approaches in genomics, proteomics and metabonomics. ! I warmly recommend this ! to all practicing toxicologists. (Roy Forster, British Toxicological Society Newsletter, June-August, 2009)
