Overview

"It is difficult to overstate the evolutionary and functional significance of mammary tissue in biology. Substantial progress has been made by researchers in various disciplines towards realizing the potential of this tissue to yield powerful experimental models for morphogenesis and tissue development; for cellular differentiation; for the biosynthesis and secretion of proteins, lipids, small molecules and inorganic salts; and for the coordination and regulation of these processes. Also, the possibility of exploiting the secretory epithelial cells of mammary tissue as ""cell factories"" has become a reality and the recombinant production by lactating animals of an increasing number of proteins, valuable both in the pharmaceutical and ""nutraceutical"" fields, is in progress or under development. This volume provides a glimpse into our understanding, at the cutting edge of a variety of disciplines, of this versatile and extraordinary tissue, at the birth of the 21st century."

Full Product Details

Author:   John A. Mol ,  Roger A. Clegg
Publisher:   Springer Science+Business Media
Imprint:   Kluwer Academic/Plenum Publishers
Edition:   2002 ed.
Volume:   480
Dimensions:   Width: 17.80cm , Height: 2.60cm , Length: 25.40cm
Weight:   1.870kg
ISBN:  

9780306464140

ISBN 10:   0306464144
Pages:   314
Publication Date:   31 August 2000
Audience:   College/higher education ,  Professional and scholarly ,  Postgraduate, Research & Scholarly ,  Professional & Vocational
Format:   Hardback
Publisher's Status:   Active
Availability:   In Print  
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Table of Contents

Fibroblast Growth Factor Signalling and Cyclin D1 Function are Necessary for Normal Mammary Gland Development during Pregnancy.- Hepatocyte Growth Factor and Neuregulin in Mammary Gland Cell Morphogenesis.- Expression and Localization of Growth Factors during Mammary Gland Development.- Involvement of Growth Factors in the Regulation of Pubertal Mammary Growth in Cattle.- Insulin-like Growth Factor Binding Protein-5 (IGFBP-5) Potentially Regulates Programmed Cell Death and Plasminogen Activation in the Mammary Gland.- Somatostatin and Opioid Receptors in Mammary Tissue.- Heparan Sulphate.- Progestin-induced Mammary Growth Hormone (GH) Production.- Translocation and Action of Polypeptide Hormones within the Nucleus.- Mammary Gland Development and the Prolactin Receptor.- Paracrine Mechanisms of Mouse Mammary Ductal Growth.- Targeting of PKA in Mammary Epithelial Cells.- The PEA3 Group of ETS-related Transcription Factors.- Transcription Factor NF 1 Expression in Involuting Mammary Gland.- The Elf Group of Ets-Related Transcription Factors.- The Role of Stat3 in Apoptosis and Mammary Gland Involution.- Synergistic and Antagonistic Interactions of Transcription Factors in the Regulation of Milk Protein Gene Expression.- Nucleosome Organisation of the ?-Lactoglobulin Gene.- Chromatin Remodeling in Hormone-Dependent and - Independent Breast Cancer Cell Lines.- The Use of Transplanted Mammary Gland to Study Cancer Signalling Pathways.- Development of Mammary Gland Requires Normal ?l-Integrin Function.- Repression of the Putative Tumor Suppressor Gene Bardl or Expression of Notch4(Int-3) Oncogene Subvert the Morphogenetic Properties of Mammary Epithelial Cells.- Oncogene Mediated Signal Transduction in Transgenic Mouse Models of Human Breast Cancer.- Caspases: Decoders ofApoptotic Signals During Mammary Involution.- The Role of Plasminogen Activator in the Bovine Mammary Gland.- Regulation and Nutritional Manipulation of Milk Fat.- Effect of Feeding Pattern and Behaviour on Hormonal Changes and Milk Composition.- Genetic Polymorphisms in Milk Protein Genes and their Impact on Milk Composition.- Mammary Gland Immunology Around Parturition.- Cells and Cytokines in Inflammatory Secretions of Bovine Mammary Gland.- Immune Surveillance of Mammary Tissue by Phagocytic Cells.- Mammary Gland Immunology And Neonate Protection In Pigs.- Relationship Between Teat Tissue Immune Defences and Intramammary Infections.- Immunological Aspectsof Pregnancy-Associated Glycoproteins.- Vaccines Against Bovine Mastitis due to Streptococcus uberis Current Status and Future Prospects..

Reviews

'...this book represents one of the best of its kind. Each chapter represents and excellent point of well-referenced initial contact to the increasing number of funded investigators interested in the biology of the mammary gland.' TRENDS in Endocrinology - Metabolism, 12:8(2001)

...this book represents one of the best of its kind. Each chapter represents and excellent point of well-referenced initial contact to the increasing number of funded investigators interested in the biology of the mammary gland.' TRENDS in Endocrinology - Metabolism, 12: 8(2001)

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