Overview

Phosphoinostides have been known to play a role in cell signalling since the 1950s and since then, lipid signals have been discovered to play a role in many different cellular functions. Biology of Phosphoinostides is not a historical account, but a review of the current opinions of lipid signalling research with the emphasis on the integration of the use of lipid signals in signal transduction and membrane trafficking. These two areas have traditionally been seen as separate but now anyone ignoring one area at the expense of the other does so at their peril. The regulation of phospholipase C (and its isozymes), phospholipase D, the phosphinositide-3-kinases, chloride channel conductance by inositol (3,4,5,6) tetraphosphate, and of cytoskeletal protein activity by inositol lipids are all covered in depth. There is specific discussion of the PH and FYVE lipid binding domains that allow lipids to control the movement, location, and activation- state of membrane proteins. The central issue of the control of synthesis, translocation, and degradation of phosphoinositides is also given due coverage. For too long, lipids have been seen as a backwater of biology and an uninteresting topic to study. However their central role in cell function is now properly recognized and the Biology of Phosphoinositides will serve as an enjoyable and intriguing introduction to what these slippery molecules can achieve.

Full Product Details

Author:   Shamshad Cockcroft (Department of Physiology, University College London)
Publisher:   Oxford University Press
Imprint:   Oxford University Press
Volume:   27
Dimensions:   Width: 18.80cm , Height: 2.20cm , Length: 24.60cm
Weight:   0.804kg
ISBN:  

9780199637645

ISBN 10:   0199637644
Pages:   366
Publication Date:   20 April 2000
Audience:   Professional and scholarly ,  Professional & Vocational
Format:   Paperback
Publisher's Status:   Out of Print
Availability:   Out of stock  

Table of Contents

Regulation of Phosphoinositide-specific Phospholipase C isozymes Phosphoinositide- 3-kinases - Regulation by cell surface receptors and function of 3-phosphorylated lipids Enzymes involved in the synthesis of phosphatidylinositol 4,5 bisphosphate and their regulation - Phosphoinositide kinases Pleckstrin Homology Domains: Phosphoinositide-regulated membrane tethers Regulation of cytoskeletal protein by inositol lipids Physiological functions phosphatidylinositol transfer proteins Glycosyl-phosphatidylinositol anchored proteins and their phospholipases Phosphatidylinositol 3 kinase and membrane traffic Regulation of Phospholipase D signalling by phosphoinositides Regulation of chloride channel conductance by inositol (3,4,5,6) tetraphosphate; A phosphoinositide-initiated signalling pathway that acts downstream of inositol (1,4,5) trisphosphate Phosphatases for inositol lipids and for inositol phosphates

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