Overview

This volume gives the reader a comprehensive overview of the fundamental and biological aspects of aging. First, the field is described from a historical perspective. Then, the author analyzes the three fundamental mechanisms of survival: energy utilization, molecular and cellular redundancy, and the organization of information. The genetics of aging is reviewed rejecting some simple-minded interpretations. A bridge is established between the molecular, cellular, and tissue modifications that have been reported in the literature, and the clinical manifestations of the aging syndrome. Special relevance is given to the problem of the supposed association between cancers and aging, giving a new interpretation of that relationship.

Full Product Details

Author:   Alvaro Macieira-Coelho
Publisher:   Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint:   Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Edition:   2003 ed.
Volume:   30
Dimensions:   Width: 15.50cm , Height: 1.20cm , Length: 23.50cm
Weight:   1.030kg
ISBN:  

9783540438274

ISBN 10:   3540438270
Pages:   192
Publication Date:   21 October 2002
Audience:   Professional and scholarly ,  College/higher education ,  Professional & Vocational ,  Postgraduate, Research & Scholarly
Format:   Hardback
Publisher's Status:   Active
Availability:   Out of print, replaced by POD  
We will order this item for you from a manufatured on demand supplier.

Table of Contents

Historical and Current Concepts of the Mechanisms of Aging.- 1.1 Rate of Living.- 1.2 Endocrine Theory.- 1.3 Weismann’s Theory.- 1.4 The Immune Theory.- 1.5 Cross-Linking.- 1.6 Free Radicals.- 1.7 Aging and Evolution.- Basic Determinants of Longevity.- 2.1 Energy Intake and Expenditure.- 2.2 The Storage and Flow of Information.- 2.3 Redundancy.- 2.4 Genetics of Aging.- Aging of the Mammalian Organism.- 3.1 Cellular Aging.- 3.2 Connective Tissue.- 3.3 The Structural Reorganization of the Mammalian Organism.- Neoplastic Growth Through the Human Life Span.- 4.1 The Clinical Age — Incidence of Neoplastic Disease.- 4.2 The Heterogeneity of Neoplastic Growth.- 4.3 Initiation of Neoplastic Growth at the Cellular Level.- 4.4 Progression of Neoplastic Disease.- 4.5 Age-Dependent Sensitivity to Carcinogens.- 4.6 Deviations from Normal Development and Neoplastic Growth.- The Centenarians.- References.

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